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Aspirin-Triggered 15-Epi-Lipoxin A4 Biosynthesis in Rat Liver Cells

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 507))

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Abstract

Aspirin (acetylsalicylic acid, ASA) is the lead non-steroidal anti-inflammatory drug (NSAID) and is widely used for relieving inflammation and mild to moderate pain and fever (1, 2). In addition to its primary actions, ASA also displays a wide range of beneficial effects including reduction of the incidence of coronary artery thrombosis and myocardial infarction and prevention of sporadic colon cancer (3,4). The anti-inflammatory, analgesic, antipyretic and cardiovascular protective properties are closely related to its ability to inhibit prostaglandin (PG) and thromboxane (TX) biosynthesis by acetylating the cyclooxygenase (COX) enzyme (5). However, not all the beneficial effects associated with ASA consumption can be ascribed to the inhibition of PG and TX biosynthesis, and the precise mechanism of action of ASA is at present still unsettled (6,7). In this regard, recent studies have demonstrated that in addition to block PG and TX production, ASA also triggers the generation of 15R-hydroxyeicosatetraenoic acid (15R-HETE) from arachidonic acid, which by transcellular routes is subsequently transformed to a novel series of eicosanoids identified as 15-epi-lipoxins (8-10). Since the formation of these eicosanoids is specific of ASA treatment, the term ASA-triggered lipoxins, abbreviated as AIL, was originally coined for these compounds (9,10). These novel ATL may effectively account for the beneficial effects of ASA and are indeed able to inhibit cell adhesion and proliferationin vitroand to block local inflammation by reducing both leukocyte adherence and infiltrationin vivo(9-15).

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Author information

Authors and Affiliations

  1. Hospital Clínic-Institut d’Investigacions Biomèdiques, August Pi i Sunyer (IDIBAPS), Barcelona, 08036, Spain

    Esther Titos, Joan Gaya & Joan Clària

  2. Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Nan Chiang & Charles N. Serhan

  3. Istituto di Patologia Medica e Medicina Mediterranea, University of Messina, Italy

    Mario Romano

  4. Química Farmacéutica Bayer S.A, Barcelona, 08036, Spain

    Gloria Pueyo

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  1. Esther Titos
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Editor information

Editors and Affiliations

  1. Wayne State University, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Lawrence J. Marnett

  3. Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. University of California-San Diego, La Jolla, California, USA

    Edward Dennis

  5. Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Charles Serhan

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Titos, E. et al. (2002). Aspirin-Triggered 15-Epi-Lipoxin A4 Biosynthesis in Rat Liver Cells. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E., Serhan, C. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology, vol 507. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0193-0_31

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  • DOI: https://doi.org/10.1007/978-1-4615-0193-0_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4960-0

  • Online ISBN: 978-1-4615-0193-0

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