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Functional coupling between Phospholipase a2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways

  • Makoto Murakami
  • Terumi Kambe-Ohkura
  • Ichiro Kudo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)

Abstract

Phospholipase A2 (PLA2) and cyclooxygenase (COX) represent the two crucial rate-limiting steps for the PG-biosynthetic pathway. To date, more than ten PLA2 and two COX isozymes have been identified in mammals. The existence of two kinetically distinct PG-biosynthetic responses, the immediate and delayed phases, implies the recruitment of different sets of biosynthetic enzymes to this pathway. A rapidly expanding body of evidence suggests that the two COXs, the constitutive COX-1 and inducible COX-2, play distinct roles in regulating AA metabolism. Generally, utilization of COX-1 is observed during the early phase of PG biosynthesis occurring within several minutes of stimulation, whereas COX-2-dependent PG generation proceeds over several hours in parallel with the induction of COX-2 expression.l-4 However, whether distinct PLA2s are utilized selectively in the different PG-biosynthetic phases and couple specifically with each COX isozyme is controversial.

Keywords

Heparan Sulfate Proteoglycan Functional Coupling Arachidonic Acid Release Cytosolic Phospholipase Secretory Phospholipase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Makoto Murakami
    • 1
  • Terumi Kambe-Ohkura
    • 1
  • Ichiro Kudo
    • 1
  1. 1.Department of Health ChemistrySchool of Pharmaceutical Sciences Showa UniversityTokyoJapan

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