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Manganese Lipoxygenase Has A Mononuclear Redox Center

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Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 507))

Abstract

Lipoxygenases catalyze dioxygenation on cis, cis—1,4-pentadiene moieties of fatty acids to cis-trans conjugated hydroperoxydienes. They are widely distributed in plants and animals (1, 2). All sequenced lipoxygenases belong to the same gene family. A characteristic feature is a non-heme metal center, which contains iron (1,2). One lipoxygenase with Mn as prosthetic metal (Mn-LO) has been discovered in the fungus Geaumannomyces graminis (3-6).

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Author information

Authors and Affiliations

  1. Department of Pharmaceutical Biosciences, Uppsala Biomedical Centre, Uppsala University, SE-75124, Uppsala, Sweden

    Chao Su & Ernst H. Oliw

  2. Department of Molecular Biology, Stockholm University, SE-10691, Stockholm, Sweden

    Margareta Sahlin

Authors
  1. Chao Su
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  2. Margareta Sahlin
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  3. Ernst H. Oliw
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Editor information

Editors and Affiliations

  1. Wayne State University, Detroit, Michigan, USA

    Kenneth V. Honn

  2. Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Lawrence J. Marnett

  3. Free University Berlin, Berlin, Germany

    Santosh Nigam

  4. University of California-San Diego, La Jolla, California, USA

    Edward Dennis

  5. Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Charles Serhan

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© 2002 Springer Science+Business Media New York

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Su, C., Sahlin, M., Oliw, E.H. (2002). Manganese Lipoxygenase Has A Mononuclear Redox Center. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E., Serhan, C. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology, vol 507. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0193-0_27

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  • DOI: https://doi.org/10.1007/978-1-4615-0193-0_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4960-0

  • Online ISBN: 978-1-4615-0193-0

  • eBook Packages: Springer Book Archive

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