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Selective Inhibition of Cyclooxygenase-2 Attenuates Expression of Inflammation-Related Genes in Cns Injury

  • M. Kerry O’Banion
  • Stephanos Kyrkanides
  • John A. Olschowka
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)

Abstract

Injury to the brain, whether arising from trauma, stroke, or infection, elicits a tissue response characterized by glial cell activation and production of inflammation-related gene products. A similar response occurs in Alzheimer’s disease, where deposits of amyloid-beta are associated with activated glia and a wide variety of inflammatory products have been detected (Neuroinflammation Working Group, 2000). The widespread use of glucocorticoids in spinal cord injury and epidemiological evidence that nonsteroidal anti-inflammatory drugs may be beneficial in Alzheimer’s disease indicate that therapies targeting inflammatory processes may be useful in treatment of central nervous system (CNS) injury and disease. Cyclooxygenase-2 (COX-2) plays a major role in peripheral inflammatory processes (Dubois et al., 1998). Tissue culture studies show that astrocytes and microglia have the capacity to express COX-2 in response to proinflammatory cytokines (O’Banion et al., 1996; O’Banion, 1999). However, little is known about the contribution of COX-2 to inflammatory processes in the CNS.

Keywords

Traumatic Brain Injury Central Nervous System Injury Glial Activation Tissue Culture Study Glial Cell Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • M. Kerry O’Banion
    • 1
    • 2
  • Stephanos Kyrkanides
    • 2
    • 3
  • John A. Olschowka
    • 2
  1. 1.Department of NeurologyUniversity of Rochester School of Medicine and DentistryRochesterUSA
  2. 2.Department of Neurobiology & AnatomyUniversity of Rochester School of Medicine and DentistryRochesterUSA
  3. 3.Eastman Department of DentistryUniversity of Rochester School of Medicine and DentistryRochesterUSA

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