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15-Lipoxygenase-1 Overexpression in Prostate Adenocarcinoma

  • Uddhav Kelavkar
  • Cynthia Cohen
  • Thomas Eling
  • Kamal Badr
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)

Abstract

Arachidonate 15-lipoxygenase[15-LO-1]oxidizes linoleic acid, arachidonic acid, membrane lipids and low density lipoprotein, reactions of potential relevance to inflammation, membrane remodeling, atherosclerosis ’ and cancer. The oxidation products of one of its substrates, linoleic acid (LA), are involved in the regulation of both physiologic and pathologic processes2-7. The major oxidative metabolite of LA is the hydroxy fatty acid 13-hydroxyoctadecadienoic acid (13-(S)-HODE) which has been associated with proliferative processes in response to growth factor treatment3.7. Buchanan et al.3have shown that tumor cell adhesivity is dependent, in part, upon the relative amounts of intracellular 13-HODE and the arachidonic acid monohydroxide(s), 12- and/or 15-hydroxyeicosatetraenoic acids (12-, 15-HETE). Arachidonic acid (AA) metabolites are similarly important mediators of a variety of physiologic processes and inflammatory reactions, including neoplastic processes8. AA is metabolized via cyclooxygenase to prostaglandins, prostacyclin, and thromboxane9and via lipoxygenases (LO) to hydroxyeicosatetraenoic acids (HETEs), leukotrienes and lipoxins (5 and15-LOpathways) ’. Four lipoxygenases are identified in humans: a 5S-LO found in leukocytes, a 12S-LO and 12R-LO found in platelets and certain epithelia, a15-LO-1in reticulocytes, eosinophils, macrophages, prostate, liver, kidney, spleen, thymus, testis, ovary, skeletal muscle, heart, brain, or intestinal tissue (Table 1) and 15-S-lipoxygenase(15-LO-2)found predominantly in benign prostate and skin10. The15-LO-1cDNA was cloned from a human reticulocyte cDNA library “ and is found in a variety of tissues, mainly of epithelial origin (Table 1).

Keywords

High Performance Liquid Chromatography Linoleic Acid Arachidonic Acid Seminal Vesicle High Performance Liquid Chromatography Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Uddhav Kelavkar
    • 1
  • Cynthia Cohen
    • 2
  • Thomas Eling
    • 3
  • Kamal Badr
    • 1
  1. 1.The Center for Glomerulonephritis, Renal DivisionEmory University and the VAMCAtlanta
  2. 2.Department of PathologyEmory UniversityAtlanta
  3. 3.Laboratory of Molecular Carcinogenesis, NIEHSResearch Triangle Park

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