Modulation of Cyclooxygenase-2 Expression by Apc In Ht-29 Human Colorectal Carcinoma Cells
Cyclooxygenase (COX) is the key enzyme in arachidonate metabolism and catalyzes the conversion of arachidonic acid to prostaglandin H2, the precursor for prostaglandins and thromboxanes’. Two isoforms of the COX enzyme exist. COX-1 is constitutively expressed in tissues while COX-2 is induced in inflammatory reactions’ dysregulated after loss of APC function.
KeywordsSodium Butyrate Colorectal Cancer Cell Line Human Colorectal Cell Line Similar Protein Loading
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