Modulation of Cyclooxygenase-2 Expression by Apc In Ht-29 Human Colorectal Carcinoma Cells

  • Linda C. Hsi
  • Julie Angerman-Stewart
  • Thomas E. Eling
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)


Cyclooxygenase (COX) is the key enzyme in arachidonate metabolism and catalyzes the conversion of arachidonic acid to prostaglandin H2, the precursor for prostaglandins and thromboxanes’. Two isoforms of the COX enzyme exist. COX-1 is constitutively expressed in tissues while COX-2 is induced in inflammatory reactions’ dysregulated after loss of APC function.


Sodium Butyrate Colorectal Cancer Cell Line Human Colorectal Cell Line Similar Protein Loading 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Linda C. Hsi
    • 1
  • Julie Angerman-Stewart
    • 1
  • Thomas E. Eling
    • 1
  1. 1.Eicosanoid Biochemistry Section Laboratory of Molecular Carcinogenesis Research Triangle ParkNational Institute of Environmental Health Sciences

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