Abstract
Human 5-lipoxygenase (5L0) catalyzes the rate determining step in the cellular production of leukotrienes and lipoxins and has therefore become an important target for pharmacological treatment of inflammatory disorders (1). Regulation of 5L0 activityin vivois complex and has been shown to involve processes such as translocation to membrane structures, redox status and the presence of certain levels of calcium ions and ATP, for review see (2).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Samuelsson, B., Dahlen, S.E., Lindgren, J.A., Rouzer, C.A. and Serhan, C.N., Leukotrienes and lipoxins: structures, biosynthesis, and biological effectsScience237: 1171–6 (1987).
Radmark, O.P., 5-Lipoxygenase, in Novel Inhibitors of Leukotrienes, G. Folco, B. Samuelsson, andR.C. Murphy, Editors. 1999, Birkhäuser Verlag: Basel. p. 1–22.
Reddy, K.V., Hammarberg, T. and Radmark, O., Mg2+ Activates 5-LipoxygenaseinVitro: Dependency on Concentrations of Phosphatidylcholine and Arachidonic AcidBiochemistry39: 1840–1848 (2000).
Maruyama, K., Mikawa, T. and Ebashi, S., Detection of calcium binding proteins by 45Ca autoradiography on nitrocellulose membrane after sodium dodecyl sulfate gel electrophoresisJournal of Biochemistry95: 511–9 (1984).
Hammarberg, T. and Radmark, O., 5-lipoxygenase binds calciumBiochemistry38: 4441–4447 (1999).
Hummel, J.P. and Dreyer, W.J., Measurement of protein-binding phenomena by gel filtrationBiochimica Biophysica Acta63: 530–532 (1962).
Percival, M.D., Denis, D., Riendeau, D. and Gresser, M.J., Investigation of the mechanism of non-turnoverdependent inactivation of purified human 5-lipoxygenase. Inactivation by H202 and inhibition by metal ionsEuropean Journal of Biochemistry210: 109–17 (1992).
Noguchi, M., Miyano, M., Matsumoto, T. and Noma, M., Human 5-lipoxygenase associates with phosphatidylcholine liposomes and modulates LTA4 synthetase activityBiochimica et Biophysica Acta1215: 300–6 (1994).
Skorey, K.I. and Gresser, M.J., Calcium is not required for 5-lipoxygenase activity at high phosphatidyl choline vesicle concentrationsBiochemistry37: 8027–34 (1998).
Zhang, Y.Y., Hamberg, M., Radmark, O. and Samuelsson, B., Stabilization of purified human 5lipoxygenase with glutathione peroxidase and superoxide dismutaseAnal Biochem220: 28–35 (1994).
Bordier, C., Phase separation of integral membrane proteins in Triton X-114 solutionJournal of Biological Chemistry256: 1604–7 (1981).
Gillmor, S.A., Villasenor, A., Fletterick, R., Sigal, E. and Browner, M.F., The structure of mammalian 15lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity [published erratum appears in Nat Struct Biol 1998 Mar;5(3):242]Nature Structural Biology4: 1003–9 (1997).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hammarberg, T., Reddy, K.V., Persson, B., Rádmark, O. (2002). Calcium Binding to 5-Lipoxygenase. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E., Serhan, C. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology, vol 507. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0193-0_19
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0193-0_19
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4960-0
Online ISBN: 978-1-4615-0193-0
eBook Packages: Springer Book Archive