Calcium Binding to 5-Lipoxygenase

  • Tove Hammarberg
  • Konda Veera Reddy
  • Bengt Persson
  • Olof Rádmark
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)


Human 5-lipoxygenase (5L0) catalyzes the rate determining step in the cellular production of leukotrienes and lipoxins and has therefore become an important target for pharmacological treatment of inflammatory disorders (1). Regulation of 5L0 activityin vivois complex and has been shown to involve processes such as translocation to membrane structures, redox status and the presence of certain levels of calcium ions and ATP, for review see (2).


Calcium Binding Equilibrium Dialysis LTA4 Hydrolase Radioactive Calcium Detergent Phase 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Tove Hammarberg
    • 1
  • Konda Veera Reddy
    • 1
  • Bengt Persson
    • 1
  • Olof Rádmark
    • 1
  1. 1.Department of Medical Biochemistry and Biophysics Karolinska InstitutetStockholmSweden

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