Substrate Down Regulation of 12-lipoxygenase in Human Platelets

  • Marina Dadaian
  • Pär Westlund
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)


Lipoxygenases are non heme iron containing enzymes which catalyze dioxygenation of unsaturated fatty acids with the production of the corresponding hydroperoxides. The main mammalian lipoxygenases are classified with respect to the positional specificity of the oxygenation of arachidonic acidI. 12-Lipoxygenase (12-LO) from human platelets was the first mammalian lipoxygenase described2however, the biological significance of this pathway in platelets is not completely understood. Furthermore, little is known about regulation of 12-lipoxygenase activity in human platelets. It has been shown that 12-LO is activated by its product, 12-hydroperoxyeicosatetraenoic acid (12-HPETE)3.


Arachidonic Acid Human Platelet Heme Iron Calcium Ionophore A23187 Positional Specificity 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Marina Dadaian
    • 1
  • Pär Westlund
    • 1
  1. 1.Department of Woman and Child Health Division of Reproductive EndocrinologyKarolinska HospitalStockholmSweden

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