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Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF, a potent epithelial Secretagogue

  • Sean P. Colgan
  • Cormac T. Taylor
  • Sailaja Narravula
  • Kristin Synnestvedt
  • Elizabeth D. Blume
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)

Abstract

Mucosal epithelial cells provide a barrier that separates lumenal and vascular compartments. This monolayer of cells provides barrier function and serves as a conduit for vectorial ion movement, the transport event underlying mucosal hydration1. By secreting solutes and transporting fluid, epithelial cells are able to coordinate compositional changes of the luminal compartment. A number of stimuli, including hormones, neurotransmitters and cytokines have been shown to directly regulate epithelial function1-3

Keywords

Okadaic Acid cAMP Response Element Binding cAMP Response Element Binding Protein Methyl Formate Mucosal Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Sean P. Colgan
    • 1
  • Cormac T. Taylor
    • 1
  • Sailaja Narravula
    • 1
  • Kristin Synnestvedt
    • 1
  • Elizabeth D. Blume
    • 2
  1. 1.Center for Experimental Therapeutics and Reperfusion InjuryBrigham and Women’s HospitalBoston
  2. 2.Department of CardiologyChildren’s Hospital and Harvard Medical SchoolBoston

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