Down-regulation of 5-lipoxygenase activity and leukotriene production by prolonged exposure to Lipopolysaccharide

  • Thomas G. Brock
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)


Eicosanoids are a diverse group of intercellular mediators derived from the enzymatic modification of arachidonic acid (AA1). The prostaglandins (PGs) and leukotrienes (LTs) are two major groups of eicosanoids. These mediators can evoke a diverse array of responses. In some cases, similar eicosanoids evoke opposing effects. For example, PGE2and prostacyclin (PGI2) promote smooth muscle relaxation, while PGD2, LTC4and thromboxane cause muscle contraction.


Smooth Muscle Relaxation Calcium Ionophore A23187 Cytosolic Phospholipase Hydroxyeicosatetraenoic Acid Multiple Organ System Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Thomas G. Brock
    • 1
  1. 1.Division of Pulmonary and Critical Care Medicine Department of Internal MedicineUniversity of MichiganAnn ArborUSA

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