Abstract
Eicosanoids are a diverse group of intercellular mediators derived from the enzymatic modification of arachidonic acid (AA1). The prostaglandins (PGs) and leukotrienes (LTs) are two major groups of eicosanoids. These mediators can evoke a diverse array of responses. In some cases, similar eicosanoids evoke opposing effects. For example, PGE2and prostacyclin (PGI2) promote smooth muscle relaxation, while PGD2, LTC4and thromboxane cause muscle contraction.
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Abbreviations: 5-LO, 5-lipoxygenase; AA, arachidonic acid; COX, cyclooxygenase; RETE, hydroxyeicosatetraenoic acid; LPS, lipopolysaccharide; L T, leukotriene; PG,prostaglandin.
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© 2002 Springer Science+Business Media New York
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Brock, T.G. (2002). Down-regulation of 5-lipoxygenase activity and leukotriene production by prolonged exposure to Lipopolysaccharide. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E., Serhan, C. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology, vol 507. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0193-0_16
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DOI: https://doi.org/10.1007/978-1-4615-0193-0_16
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