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Cyclooxygenase-2 Expression and Activity are Induced by Amyloid-Beta 1-42 in Brain-Derived Cells

  • MacKenzie Hilfers Bilunas
  • Steven A. Moore
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)

Abstract

One of the early events in Alzheimer’s disease (AD) is the extracellular deposition of amyloid-beta peptide (An), a 39- to 43- amino acid cleavage product of the transmembrane glycoprotein, amyloid precursor protein. Excess A13 within the brain has long been thought to play a major role in AD pathogenesis, however, the mechanisms of its actions are highly debatable. Recent evidence suggests that inflammation may be the pathogenetic link between AP deposition and neuronal death (Halliday et al., 2000).

Keywords

Ribonuclease Protection Assay Cerebral Endothelium Essential Fatty Acid Precursor Cerebrovascular Cell Vascular Cell Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • MacKenzie Hilfers Bilunas
    • 1
  • Steven A. Moore
    • 1
  1. 1.Department of PathologyThe University of IowaIowa CityIA

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