Inhibition of 5-lo Activating Protein (Flap) Activity Decreases Proteinuria in Streptozotocin(Stz)-induced Diabetic Rats.

  • José M. Valdivielso
  • Angel Montero
  • Karen A. Munger
  • Kamal F. Badr
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 507)


Proteinuria is a major cause of morbidity in patients with glomerular disease. Nonselective protein filtration is now recognized as a significant contributing factor to the tubulo-interstitial injury which underlies and often predicts progressive renal insufficiency in patients with primary glomerular diseases. Increasing recognition of the mechanisms whereby proteinuria leads to tubule injury confirms the well-known clinical observation that the magnitude of proteinuria at diagnosis is a reliable predictor of prognosis in patients with glomerulonephritis and diabetes. For this reason, the search for safe and effective anti-proteinuric agents which do not reduce the glomerular filtration rate represents an urgent and critical need for physicians involved in the care of patients with glomerular disorders.


Blood Urea Nitrogen Proliferative Glomerulonephritis Significant Contribute Factor Tubule Injury Progressive Renal Insufficiency 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • José M. Valdivielso
    • 1
  • Angel Montero
    • 1
  • Karen A. Munger
    • 1
  • Kamal F. Badr
    • 1
  1. 1.Center for GlomerulonephritisEmory University School of MedicineAtlanta

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