A Novel Neuromodulator in Basal Ganglia
Cannabinoids are a family of compounds that naturally occur in the marihuana plant(Cannabis sativa)and produce their effects through recently cloned G-coupled cannabinoid receptors (Matsuda et al. 1990; Munro et al. 1993). Of the myriad of physiological actions of cannabinoids, the motor effects seem to be mediated by the neural CB1 cannabinoid receptor (Rinaldi-Carmona et al. 1994, Compton et al. 1996). In general, activation of CB1 receptors by cannabinoid agonists inhibits neurotransmission through various mechanisms: by inhibition of adenylate cyclase thus decreasing the cellular levels of cAMP (Howlett et al 1995), by activation of K+ channels thus decreasing the excitability of the cell (Deadwyler et al. 1993), and by inhibition of N/Q Ca2+ channels thus inhibiting neurotransmitter release (Mackie et al 1992).
KeywordsToxicity Dopamine Amide NMDA Chlordiazepoxide
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