A Novel Neuromodulator in Basal Ganglia

  • M. Clara Sañudo-Peña
Part of the Advances in Behavioral Biology book series (ABBI, volume 54)


Cannabinoids are a family of compounds that naturally occur in the marihuana plant(Cannabis sativa)and produce their effects through recently cloned G-coupled cannabinoid receptors (Matsuda et al. 1990; Munro et al. 1993). Of the myriad of physiological actions of cannabinoids, the motor effects seem to be mediated by the neural CB1 cannabinoid receptor (Rinaldi-Carmona et al. 1994, Compton et al. 1996). In general, activation of CB1 receptors by cannabinoid agonists inhibits neurotransmission through various mechanisms: by inhibition of adenylate cyclase thus decreasing the cellular levels of cAMP (Howlett et al 1995), by activation of K+ channels thus decreasing the excitability of the cell (Deadwyler et al. 1993), and by inhibition of N/Q Ca2+ channels thus inhibiting neurotransmitter release (Mackie et al 1992).


Basal Ganglion Globus Pallidus Subthalamic Nucleus Contralateral Rotation Entopeduncular Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • M. Clara Sañudo-Peña
    • 1
  1. 1.The Alan M. Schrier Research Laboratory, Department of PsychologyBrown UniversityProvidenceUSA

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