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Leptin and Reproduction pp 133–150Cite as

Leptin and Pubertal Development in Higher Primates

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Abstract

According to Romer’s classification (Romer, 1959), higher primates are comprised of three families; namely Cercopithecidae (Old World monkeys), Simiidae (man-like apes), and Hominidae (human). Although puberty in these mammalian families, as in nonprimate species, is defined as the period of becoming first capable of reproducing sexually, the mechanism that times the onset of this developmental milestone in monkeys, apes, and man appears to be unique to higher primates (Plant, 1994). The distinguishing feature of puberty in higher primates, as exemplified in our own species, is that despite a competent hypothalamic-pituitary-gonadal axis during the greater part of prepubertal development, the initiation of robust sex steroid production in association with gametogenesis is delayed for years. The delay of puberty in monkeys and man is occasioned at the hypothalamic level by a prolonged reduction in the activity of the neuronal network governing gonadotropin-releasing hormone (GnRH) release that extends from infancy until termination of the juvenile phase of development. Puberty in primates thus comprises the subsequent re-augmentation of pulsatile GnRH release and the profound sequelae set in motion by this neurobiological event (Plant, 1994).

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Authors and Affiliations

  1. Department of Physiology and the Cooperative Reproductive Science Research Center, Morehouse School of Medicine, USA

    David R. Mann

  2. Department of Cell Biology and Physiology and the Specialized Cooperative Center Program of Reproduction Research, University of Pittsburgh Medical School, USA

    Tony M. Plant

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  1. Tulane University Health Sciences Center, New Orleans, Louisiana, USA

    Michael C. Henson

  2. Texas Tech Health Sciences Center, Amarillo, Texas, USA

    V. Daniel Castracane

  3. Diagnostic Systems Laboratories, Inc., Webster, Texas, USA

    V. Daniel Castracane

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Mann, D.R., Plant, T.M. (2003). Leptin and Pubertal Development in Higher Primates. In: Henson, M.C., Castracane, V.D. (eds) Leptin and Reproduction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0157-2_9

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