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Leptin and Reproduction pp 77–95Cite as

Impact of Leptin on Ovarian Folliculogenesis and Assisted Reproduction

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Abstract

With the discovery in the late 1990s that leptin receptors are expressed in high levels within maturing follicles, it became clear that leptin may regulate ovarian function at multiple levels. Not only does leptin participate in the control of gonadotropin secretion via its hypothalamic actions, but circulating or locally produced leptin may also provide direct modulation of thecal, granulosa, and oocyte function. Addition of leptin to the growing list of cytokines and growth factors involved in follicular development and oocyte maturation extends our appreciation of the complex integration of basic cellular and metabolic processes with reproductive function and fertility.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of South Dakota School of Medicine, USA

    John D. Brannian & Keith A. Hansen

Authors
  1. John D. Brannian
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  2. Keith A. Hansen
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Editors and Affiliations

  1. Tulane University Health Sciences Center, New Orleans, Louisiana, USA

    Michael C. Henson

  2. Texas Tech Health Sciences Center, Amarillo, Texas, USA

    V. Daniel Castracane

  3. Diagnostic Systems Laboratories, Inc., Webster, Texas, USA

    V. Daniel Castracane

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© 2003 Springer Science+Business Media New York

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Brannian, J.D., Hansen, K.A. (2003). Impact of Leptin on Ovarian Folliculogenesis and Assisted Reproduction. In: Henson, M.C., Castracane, V.D. (eds) Leptin and Reproduction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0157-2_5

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  • DOI: https://doi.org/10.1007/978-1-4615-0157-2_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4946-4

  • Online ISBN: 978-1-4615-0157-2

  • eBook Packages: Springer Book Archive

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