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Endocrine Regulation of Leptin Production

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Leptin and Reproduction

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Abstract

The LEP gene (originally termed ob gene in rodents) was discovered through a molecular genetics search for the defective gene that resulted in morbid obesity in ob/ob mice (Zhang et al., 1994). Early observations demonstrated that leptin, the protein product of the LEP gene, was synthesized by adipose tissue and released into the bloodstream to provide a signal to the central nervous system of the size of the adipose tissue mass, thus linking energy stores to mechanisms regulating energy intake and expenditure (reviewed in Matson et al., 1996; Considine and Caro, 1997; Friedman, 1998). It has since been recognized that leptin can be synthesized by cells other than adipocytes, and that this hormone participates in other physiologic processes (Considine and Caro, 1999). A substantial amount of work has provided insight into the mechanisms that regulate leptin synthesis and secretion from the adipose tissue, although many details remain to be elucidated. This chapter will summarize the endocrine regulation of leptin production in adipose tissue, focusing on findings in humans and human tissue manipulated in vitro. Regulation of leptin synthesis in tissues other than adipose tissue, and the possible regulatory function(s) of the hormone produced by these tissues will be discussed.

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  1. Department of Medicine, Indiana University School of Medicine, USA

    Robert V. Considine

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  1. Tulane University Health Sciences Center, New Orleans, Louisiana, USA

    Michael C. Henson

  2. Texas Tech Health Sciences Center, Amarillo, Texas, USA

    V. Daniel Castracane

  3. Diagnostic Systems Laboratories, Inc., Webster, Texas, USA

    V. Daniel Castracane

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Considine, R.V. (2003). Endocrine Regulation of Leptin Production. In: Henson, M.C., Castracane, V.D. (eds) Leptin and Reproduction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0157-2_3

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