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Leptin in Primate Pregnancy

  • Chapter
Leptin and Reproduction

Abstract

Leptin is a polypeptide hormone once considered to be an exclusive product of adipose tissue, it’s sole function being to aid in the maintenance of energy homeostasis through the induction of satiety (Considine and Caro, 1997; Weigle, 1997). Mutations in the leptin (ob) gene are responsible for a lack of circulating leptin and for obesity in homozygous (ob/ob) mice (Zhang et al., 1994), with some cases of human obesity potentially corresponding to a similar mechanism (Montague et al., 1997; Rosenbaum and Leibel, 1998). Most cases of human obesity exhibit a state of “leptin resistance,” which may result from any of a number of potential causes (Ahima and Flier, 2000). Regulatory mechanisms remain incompletely defined, although interactions with various hormones are known to affect leptin’s ability to regulate adipose energy reserves (Jequier and Tappy, 1999; Moschos et al., 2002).

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Authors and Affiliations

  1. Departments of Obstetrics and Gynecology, Physiology, and Structural and Cellular Biology, and the Tulane National Primate Research Center, Tulane University Health Sciences Center, USA

    Michael C. Henson

  2. Department of Obstetrics and Gynecology, and the Women’s Health Research Institute of Amarillo, Texas Tech University Health Sciences Center—Amarillo; Diagnostic Systems Laboratories, Inc., USA

    V. Daniel Castracane

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  1. Michael C. Henson
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  2. V. Daniel Castracane
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Editors and Affiliations

  1. Tulane University Health Sciences Center, New Orleans, Louisiana, USA

    Michael C. Henson

  2. Texas Tech Health Sciences Center, Amarillo, Texas, USA

    V. Daniel Castracane

  3. Diagnostic Systems Laboratories, Inc., Webster, Texas, USA

    V. Daniel Castracane

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© 2003 Springer Science+Business Media New York

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Henson, M.C., Castracane, V.D. (2003). Leptin in Primate Pregnancy. In: Henson, M.C., Castracane, V.D. (eds) Leptin and Reproduction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0157-2_15

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  • DOI: https://doi.org/10.1007/978-1-4615-0157-2_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4946-4

  • Online ISBN: 978-1-4615-0157-2

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