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Developments in Tryptophan and Serotonin Metabolism pp 337–345Cite as

The Influence of L - Tryptophan Peroral Load on Glomerular Filtration Rate in Chronic Glomerulonephritis and Chronic Renal Failure

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 527))

Abstract

The results of our clinical observations of 102 patients with chronic glomerulonephritis with normal renal function and 10 patients with chronic renal failure, as well as 10 healthy individuals allow us to conclude that in patients with high proteinuria and impaired renal function the serum concentration of tryptophan is decreased, both before and after peroral L ¡ª tryptophan load. We have found a positive correlation between serum concentration of albumin and tryptophan in patients with normal kidney function, and negative correlations between serum concentration of albumin and intensity of proteinuria, as well as between serum concentration of tryptophan and proteinuria.

Our studies have shown that L ¡ª tryptophan peroral load increases the glomerular filtration rate in healthy individuals, in patients with membronous proliferative glomerulonephritis with proteinuria < 2 g/24 h and mesangioproliferative glomerulonephritis with proteinuria < 2 g/24 h. In patients with high proteinuria (> 2 g/ 24h) and decreased renal function L ¡ª tryptophan load does not influence the glomerular filtration rate.

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Authors and Affiliations

  1. Latvia Medical Academy, Latvia, Riga, Kuldigas 23-4

    Agris Martinsons

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  1. Agris Martinsons
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  2. Vera Rudzite
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  3. Harijis Cernevskis
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  4. Inese Mihailova
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  5. Zane Smeltere
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Editors and Affiliations

  1. University of Padova, Padova, Italy

    Graziella Allegri , Carlo V. L. Costa  & Eugenio Ragazzi ,  & 

  2. University of Hamburg, Hamburg, Germany

    Hans Steinhart

  3. Istituto G. Gaslini, Genova Quarto, Italy

    Luigi Varesio

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Martinsons, A., Rudzite, V., Cernevskis, H., Mihailova, I., Smeltere, Z. (2003). The Influence of L - Tryptophan Peroral Load on Glomerular Filtration Rate in Chronic Glomerulonephritis and Chronic Renal Failure. In: Allegri, G., Costa, C.V.L., Ragazzi, E., Steinhart, H., Varesio, L. (eds) Developments in Tryptophan and Serotonin Metabolism. Advances in Experimental Medicine and Biology, vol 527. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0135-0_37

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  • DOI: https://doi.org/10.1007/978-1-4615-0135-0_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4939-6

  • Online ISBN: 978-1-4615-0135-0

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