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Developments in Tryptophan and Serotonin Metabolism pp 307–315Cite as

Prognostic Value of Tryptophan Load Test Followed by Serum Kynurenine Determination. It’s Comparison With Pyridoxal-5-phosphate, Kynurenine, Homocysteine and Neopterin Amounts

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 527))

Abstract

Tryptophan load test followed by serum kynurenine determination at fasting state and after L-tryptophan loading, as well as serum pyridoxal-5-phosphate (P-5-P), homocysteine and neopterin concentrations at fasting state have been examined in 30 healthy individuals and 87 patients with coronary heart disease (CHD), verified by coronary angiography. Received results have shown that low serum P-5-P concentration as well as P-5-P deficiency identified by tryptophan load test have been found in 78% of CHD patients, while increased homocysteine concentration above 15 µmol/L in 31.8%, and elevated neopterin concentration above 8.7 nmol/L in 32.1% of cases. It allows to conclude that a lot of CHD patients have P-5-P deficiency. Moreover P-5-P deficiency is an earlier indicator of CHD than increased homocysteine level above 15.tmol/L. Elevated serum neopterin concentration above 8.7 nmol/L may be a marker of coronary disease activity rather than a marker of the presence of CHD.

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Authors and Affiliations

  1. Latvian Institute of Cardiology, Laboratory of Biochemistry, Pilsonu Street 13, LV 1002, Riga, Latvia

    Vera Rudzite, Uldis Kalnins, Edite Jurika, Anita Silava, Andrejs Erglis, Karlis Trusinskis & Sanda Jegere

  2. lnstitute of Medical Chemistry, Biochemistry University of Innsbruck, Fritz Pregl Street 3, A-6020, Innsbruck, Austria

    Dietmar Fuchs

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  1. Vera Rudzite
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Editors and Affiliations

  1. University of Padova, Padova, Italy

    Graziella Allegri , Carlo V. L. Costa  & Eugenio Ragazzi ,  & 

  2. University of Hamburg, Hamburg, Germany

    Hans Steinhart

  3. Istituto G. Gaslini, Genova Quarto, Italy

    Luigi Varesio

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Rudzite, V. et al. (2003). Prognostic Value of Tryptophan Load Test Followed by Serum Kynurenine Determination. It’s Comparison With Pyridoxal-5-phosphate, Kynurenine, Homocysteine and Neopterin Amounts. In: Allegri, G., Costa, C.V.L., Ragazzi, E., Steinhart, H., Varesio, L. (eds) Developments in Tryptophan and Serotonin Metabolism. Advances in Experimental Medicine and Biology, vol 527. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0135-0_34

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  • DOI: https://doi.org/10.1007/978-1-4615-0135-0_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4939-6

  • Online ISBN: 978-1-4615-0135-0

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