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A Role for Glutamate Transporters in Neurodegenerative Diseases

  • Davide Trotti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 513)

Abstract

In the mammalian central nervous system (CNS) L-glutamic acid acts as a chemical transmitter of excitatory signals. L-glutamate is released in the synaptic cleft and activates a multitude of highly integrated signaling pathways by binding to an array of iono-and metabotropic glutamate receptors. The termination of this chemical neurotransmission occurs via uptake of glutamate by specialized carrier proteins. The reuptake mechanism is capable of maintaining glutamate at levels below 1 p.M in the synaptic cleft. Cells in the CNS possess unique Na+- and K+-coupled transporters with high affinity for glutamate.1 These glutamate transporters are distinct from the recently identified vesicular glutamate transporters, which belong to the family of Na+/phosphate and sulphate transporters.

Keywords

Amyotrophic Lateral Sclerosis Glutamate Transporter Synaptic Cleft Glutamate Uptake Transient Global Cerebral Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Davide Trotti
    • 1
  1. 1.DepartmentofNeurology, Cecil B. Day Laboratory for Neuromuscular ResearchMassachusetts General Hospital, Harvard Medical SchoolCharlestown

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