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Intracellular Ca2+ Handling

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Molecular and Cellular Biology of Neuroprotection in the CNS

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 513))

Abstract

Intracellular Ca2+ is regulated within three major compartments: the cytosol, the endoplasmic reticulum and mitochondria. This Chapter reviews the mechanisms involved in handling of Ca2+ within these compartments with reference to potential strategies for neuroprotection. In the cytosol, Ca2+ buffering has a major influence on Ca2+ signals. Cytosolic Ca2+-binding proteins such as CB28 participate in Ca2+ buffering and may have a role in resistance to neurotoxicity. In the endoplasmic reticulum, a number of proteins are involved in Ca2+ uptake, lumenal buffering or release, and these may be of value as potential targets for therapeutic intervention. Mitochondria are receiving increasing attention for their role in Ca2+ storage and signaling, and as key players in the processes leading to cell death following Ca2+ overload. An improved understanding of how Ca2+ is controlled within these intracellular compartments, and how these compartments interact, will be important for neuroprotective strategies.

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  1. Department of Physiology, University of Otago, P.O. Box 913, Dunedin, New Zealand

    Rod J. Sayer

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  1. Institute of Physiology, University of Kiel, Kiel, Germany

    Christian Alzheimer

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Sayer, R.J. (2003). Intracellular Ca2+ Handling. In: Alzheimer, C. (eds) Molecular and Cellular Biology of Neuroprotection in the CNS. Advances in Experimental Medicine and Biology, vol 513. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0123-7_6

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  • DOI: https://doi.org/10.1007/978-1-4615-0123-7_6

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