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Neuronal Survival and Cell Death Signaling Pathways

  • Richard S. Morrison
  • Yoshito Kinoshita
  • Mark D. Johnson
  • Saadi Ghatan
  • Joseph T. Ho
  • Gwenn Garden
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 513)

Abstract

Neuronal viability is maintained through a complex interacting network of signaling pathways that can be perturbed in response to a multitude of cellular stresses. A shift in the balance of signaling pathways after stress or in response to pathology can have drastic consequences for the function or the fate of a neuron. There is significant evidence that acutely injured and degenerating neurons may die by an active mechanism of cell death. This process involves the activation of discrete signaling pathways that ultimately compromise mitochondrial structure, energy metabolism and nuclear integrity. In this review we examine recent evidence pertaining to the presence and activation of anti-and pro-cell death regulatory pathways in nervous system injury and degeneration.

Keywords

Amyotrophic Lateral Sclerosis Nerve Growth Factor Neuronal Apoptosis Neuronal Survival Spinal Muscular Atrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Richard S. Morrison
    • 1
  • Yoshito Kinoshita
    • 2
  • Mark D. Johnson
    • 2
  • Saadi Ghatan
    • 1
  • Joseph T. Ho
    • 1
  • Gwenn Garden
    • 2
  1. 1.Department ofNeurological SurgeryUniversity of Washington School of MedicineWashington
  2. 2.Department of NeurologyUniversity of Washington School of MedicineSeattle

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