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Neuroprotective Strategies in Alzheimer’s Disease

  • Christian Behl
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 513)

Abstract

Alzheimer s disease (AD) is a deadly progressive neurodegenerative disorder. Various aspects of the biochemistry of the AD-associated amyloid ß protein (Aß) are well-described and understood. The deposition of Aß in the AD brain is one crucial hallmark of AD pathology. Consequently, the processes of the generation of Aß are the main targets for novel avenues of prevention and treatment. Besides the increasing amount of genetic information on familial forms of AD including those types caused by mutations in the AD genes APP, PSI and PS2, various genetic and non-genetic risk factors have been described. Worldwide efforts to block Aß generation or to block its deposition by immunization are of great interest but are still at a more or less experimental stage. In addition, it may be argued that the sporadic and strictly age-related forms of AD develop because the overall homeostasis of neuroprotection is disturbed rendering the nerve cells more vulnerable for exogenous insults including All Therefore, it is also wise to study neuroprotective factors and to decipher how such factors, including neurotrophins and the female sex hormone estrogen, transduce their signal leading to nerve cell protection. The identification of potential protective genes that are regulated by well known neuroprotective signals may elucidate novel targets for preventive approaches. A general and subtle neuroprotection may stabilize nerve cell survival and may leave the neurons more resistant to AD-associated pathogenetic insults.

Keywords

Alzheimer Disease Senile Plaque Oxidative Stress Hypothesis Neuronal Insulin Receptor Nongenetic Risk Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Christian Behl
    • 1
  1. 1.Max Planck Institute of PsychiatryKraepelinstrasse 2-10MunichGermany

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