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Ischemia and Stroke

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Molecular and Cellular Biology of Neuroprotection in the CNS

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 513))

Abstract

Cell death following cerebral ischemia is mediated by a complex pathophysiologic interaction of different mechanisms. In this Chapter we will outline the basic principles as well as introduce in vitro and in vivo models of cerebral ischemia. Mechanistically, excitotoxicity, peri-infarct depolarization, inflammation and apoptosis seem to be the most relevant mediators of damage and are promising targets for neuroprotective strategies.

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  1. Experimental Neurology, Charit, Humboldt-University of Berlin, D-10098, Berlin, Germany

    Matthias Endres & Ulrich Dirnagl

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  1. Matthias Endres
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  2. Ulrich Dirnagl
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  1. Institute of Physiology, University of Kiel, Kiel, Germany

    Christian Alzheimer

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Endres, M., Dirnagl, U. (2003). Ischemia and Stroke. In: Alzheimer, C. (eds) Molecular and Cellular Biology of Neuroprotection in the CNS. Advances in Experimental Medicine and Biology, vol 513. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0123-7_17

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  • DOI: https://doi.org/10.1007/978-1-4615-0123-7_17

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