Ischemia and Stroke

  • Matthias Endres
  • Ulrich Dirnagl
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 513)


Cell death following cerebral ischemia is mediated by a complex pathophysiologic interaction of different mechanisms. In this Chapter we will outline the basic principles as well as introduce in vitro and in vivo models of cerebral ischemia. Mechanistically, excitotoxicity, peri-infarct depolarization, inflammation and apoptosis seem to be the most relevant mediators of damage and are promising targets for neuroprotective strategies.


Nitric Oxide Cerebral Ischemia Middle Cerebral Artery Occlusion Circulatory Arrest Global Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Matthias Endres
    • 1
  • Ulrich Dirnagl
    • 1
  1. 1.Experimental Neurology, CharitHumboldt-University of BerlinBerlinGermany

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