TGF-ßS and Their Roles in the Regulation of Neuron Survival

  • Klaus Unsicker
  • Kerstin Krieglstein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 513)


Transforming growth factor-ßs (TGF-ßs) are a still growing superfamily of cytokines with widespread distribution and diverse biological functions. They fall into several subfamilies including the TGF-ßs 1, 2, and 3, the bone morphogenetic proteins (BMPs), the growth/differentiation factors (GDFs), activins and inhibins, and the members of the glial cell line-derived neurotrophic factor family. Following a brief description of their general roles and signaling in development, maintenance of homeostasis, and disease, we shall focus on their distribution in the CNS and their involvement in regulating neuron survival and death.


Neurotrophic Factor Transform Growth Factor Beta Chromaffin Cell Radial Glia Midbrain Dopaminergic Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Klaus Unsicker
    • 1
  • Kerstin Krieglstein
    • 2
  1. 1.Neuroanatomy and Interdisciplinary Center for Neurosciences (IZN)University of Heidelberg, Im NeuenheimerHeidelbergGermany
  2. 2.Department of Anatomy and NeuroanatomyUniversity ofG ttingenG ttingenGermany

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