Fibroblast Growth Factors and Neuroprotection

  • Christian Alzheimer
  • Sabine Werner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 513)


The FGFs comprise a large group of structurally similar polypeptide mitogens which currently includes 22 different members. The first members of this family, FGF1 (acidic FGF, aFGF) and FGF2 (basic FGF, bFGF), were described in 1986 by Jaye et all and Abraham et al.2 In the meantime, 20 other FGFs have been discovered which were designated FGF3 FGF23. FGF19 has so far only been described in humans and FGF 15 only in mice, and it has been suggested that FGF 19 is the human ortholog of mouse FGF 15. All members of the FGF family range in molecular weight from 17 to 34 kDa in vertebrates, and some of them are glycosylated (for review see ref. 3).


Hippocampal Neuron Basic Fibroblast Growth Factor Kainic Acid Cortical Spreading Depression Reduce Infarct Size 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Christian Alzheimer
    • 1
    • 2
  • Sabine Werner
    • 3
  1. 1.Institute of PhysiologyUniversity of MunichMunichGermany
  2. 2.Institute of PhysiologyUniversity ofKielKielGermany
  3. 3.Institute of Cell BiologyETH-Z rich, Hnggerber gZurichSwitzerland

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