Neurotrophins

  • Georg Dechant
  • Harald Neumann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 513)

Abstract

Nerve growth factor was the first identified protein with anti-apoptotic activity on neurons. This prototypic neurotrophic factor, together with the three structurally and functionally related growth factors brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) and neurotrophin-4/5 (NT4/5), forms the neurotrophin protein family. TargeT cells for neurotrophins include many neurons affected by neurodegenerative diseases such as Alzheimer s disease, Parkinson s disease, amyotrophic lateral sclerosis and peripheral polyneuropathies. In addition, the neurotrophins act on neurons affected by other neurological and psychiatric pathologies including ischemia, epilepsy, depression and eating disorders. Work with cell cultures and animal models provided solid support for the hypothesis that neurotrophins prevent neuronal death. While no evidence exists that a lack of neurotrophins underlies the etiology of any neurodegenerative disease, these studies have spurred on hopes that neurotrophins might be useful symptomatic-therapeutic agents. However first clinical trials led to variable results and severe side effects were observed. For future therapeutic use of the neurotrophins it is therefore crucial to expand our knowledge about their physiological functions as well as their pharmacokinetic properties. A major challenge is to develop methods for their application in effective doses and in a precisely timed and localized fashion.

Keywords

Toxicity Depression Dopamine Tyrosine Cystein 

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Georg Dechant
    • 1
  • Harald Neumann
    • 2
    • 3
  1. 1.NeurobiochemistryMax-Planck-Institute of NeurobiologyMartinsriedGermany
  2. 2.NeuroimmunologyMax-Planck-Institute of NeurobiologyMartinsriedGermany
  3. 3.NeuroimmunologyEuropean Neuroscience Institute G ttingenG ttingenGermany

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