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Pathological Roles Of Recoverin In Cancer-Associated Retinopathy

  • Hiroshi Ohguro
  • Mitsuru Nakazawa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 514)

Abstract

Cancer associated retinopathy (CAR) is an ocular manifestation of paraneoplastic syndrome clinically characterized by progressive visual impairment similar to retinitis pigmentosa. As a possible mechanism causing the retinal degeneration, the presence of serum autoantibodies against recoverin and other retinal antigens are involved. The molecular pathology in CAR by anti-recoverin antibody is considered to occur in the following steps: Firstly, recoverin aberrantly expressed in cancerous tissues is recognized by immunocytes by some unknown mechanisms and then a specific antibody toward recoverin is produced. Secondly, the anti-recoverin antibody reaches the retina via the peripheral circulation and is taken up into photoreceptor cells. Lastly, the antibody blocks recoverin function (inhibition of rhodopsin phosphorylation in a calcium dependent manner), and enhancement of rhodopsin phosphorylation induces retinal apoptosis.

Keywords

Photoreceptor Cell Retinal Degeneration Outer Nuclear Layer Paraneoplastic Syndrome Inner Nuclear Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Hiroshi Ohguro
    • 1
  • Mitsuru Nakazawa
    • 1
  1. 1.Departments of OphthalmologyHirosaki University School of MedicineHirosakiJapan

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