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Photoreceptor Degeneration and Ca2+ Influx Through Light-Activated Channels of Drosophila

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Photoreceptors and Calcium

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 514))

Abstract

We discuss in this chapter the role of Ca2+homeostasis in maintaining the structural integrity of photoreceptor cells inDrosophila.Both insufficient and excessive amounts of Ca2+in photoreceptor cells appear to lead to cell degeneration. Because one of the two classes of light-sensitive channels inDrosophilaphotoreceptors is highly Ca2+-permeable, how well this class of channels functions can profoundly affect Ca2+homeostasis. We will begin by reviewingDrosophilaphototransduction, emphasizing what is known about the mechanism of activation of light-sensitive channels. We will then describe Ca2+entry through light-sensitive channels and the presumed mechanisms by which too Iittle and too much Ca2+entry can both cause photoreceptor degeneration. We will conclude the chapter with discussions of two examples of mutations known to cause unregulated Ca2+entry through light-sensitive channels, leading to massive photoreceptor degeneration.

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Authors and Affiliations

  1. Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA

    Chaoxian Geng & William L. Pak

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  1. Chaoxian Geng
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  2. William L. Pak
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Editors and Affiliations

  1. Moran Eye Center/EIHG, University of Utah Health Science Center, 15 North/ 2030 East, Salt Lake City, UT, 84112-5330, USA

    Wolfgang Baehr Ph.D.

  2. Department of Ophthalmology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA

    Krzysztof Palczewski Ph.D.

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Geng, C., Pak, W.L. (2002). Photoreceptor Degeneration and Ca2+ Influx Through Light-Activated Channels of Drosophila . In: Baehr, W., Palczewski, K. (eds) Photoreceptors and Calcium. Advances in Experimental Medicine and Biology, vol 514. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0121-3_33

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  • DOI: https://doi.org/10.1007/978-1-4615-0121-3_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4933-4

  • Online ISBN: 978-1-4615-0121-3

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