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The Complex of cGMP-Gated Channel and Na+/ Ca2+K+Exchanger in Rod Photoreceptors

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Book cover Photoreceptors and Calcium

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 514))

Abstract

Ca2+is an important signal ion in photoreceptors for recovery after excitation and light adaptation. It enters the outer segment as a minor fraction of the dark current through cGMP-gated channels and is extruded in the same cell compartment by Na+/Ca2+K+exchange. Channel and exchanger are located exclusively in the plasma membrane, but not in the cytoplasmic membrane stack, the discs, which contain the visual pigment rhodopsin. The channel consists presumably of two a-subunits and two n-subunits, whereas the exchanger is a monomeric protein. Recently, considerable evidence has been accumulated indicating that both proteins form a complex which is bound to peripherin/rds, an integral protein of the disc rim. This review focuses on the complex of cGMP-gated channel and Na+/Ca2+K+exchanger. The possibility of direct functional interaction between channel and exchanger is discussed. Furthermore, the consequences of different subunit arrangements of the channel for the channel-exchanger complex are considered. Finally, a Ca2+diffusion model is presented which examines the possibility that Ca2+currents are locally restricted to the close vicinity of the channel.

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  1. Institute for Biological Information Processing (IBI-l), Research Center, Juelich, D-52425, Gennany

    Paul J. Bauer

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  1. Paul J. Bauer
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Editors and Affiliations

  1. Moran Eye Center/EIHG, University of Utah Health Science Center, 15 North/ 2030 East, Salt Lake City, UT, 84112-5330, USA

    Wolfgang Baehr Ph.D.

  2. Department of Ophthalmology, University of Washington, 1959 NE Pacific St., Seattle, WA, 98195, USA

    Krzysztof Palczewski Ph.D.

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Bauer, P.J. (2002). The Complex of cGMP-Gated Channel and Na+/ Ca2+K+Exchanger in Rod Photoreceptors. In: Baehr, W., Palczewski, K. (eds) Photoreceptors and Calcium. Advances in Experimental Medicine and Biology, vol 514. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0121-3_15

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  • DOI: https://doi.org/10.1007/978-1-4615-0121-3_15

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