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Neuropilin and Its Ligands in Normal Lung and Cancer

  • Joëlle Roche
  • Harry Drabkin
  • Elisabeth Brambilla
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 515)

Abstract

Neuropilins (NRPs) are receptors for class 3 Semaphorins and function as co-receptors for Vascular endothelial growth factor isoforms, VEGF165 and VEGF145 and related molecules. NRPs are expressed in a variety of neural and non-neural tissues and are required for normal development. Interestingly, class 3 Semaphorins and VEGF compete for common NRP binding. As a consequence, Semaphorins and VEGF appear to be mutually antagonistic. In the lung, NRP levels increase during development and NRPs and Semaphorins are involved in lung branching, probably by altering cell morphology or by regulating cell motility and migration. During lung tumorigenesis, both NRP and VEGF expression increase on dysplastic lung epithelial cells; SEMA3F expression is reduced and SEMA3F protein is delocalized from the membrane to the cytoplasm. In lung cancers, SEMA3F staining correlates inversely with tumor stage with high SEMA3F associated with less aggressive tumors. Conversely, more aggressive tumors are associated with increased VEGF staining and a corresponding loss in membranous SEMA3F.

Keywords

Vascular Endothelial Growth Factor Normal Lung Lung Development Lung Tumorigenesis Vascular Endothelial Growth Factor Isoforms 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Joëlle Roche
    • 1
  • Harry Drabkin
    • 2
  • Elisabeth Brambilla
    • 3
  1. 1.Université de PoitiersPoitiers CédexFrance
  2. 2.Division of Medical OncologyUniversity of Colorado Health Sciences CenterDenverUSA
  3. 3.Laboratoire de Pathologie CellulaireINSERM EMI, CHRU GrenobleGrenoble Cédex 09France

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