Abstract
The Neuropilin-1 (NRP 1) and Neuropilin-2 (NRP2) receptors were initially described as receptors for axon guidance factors belonging to the class-3 Semaphorin sub-family. Subsequently, it was found the Neuropilins also function as receptors for some forms of vascular endothelial growth factor (VEGF). VEGF165 binds to both NRP 1 and to NRP2 but VEGF121 does not bind to either of these receptors. VEGF145 on the other hand, binds to NRP2 but not to NRP1. Additional VEGF family members such as the heparin binding form of placenta growth factor (PIGF2) and VEGF-B bind to NRP 1, and it was also shown that both PIGF-2 and VEGFC bind to NRP2.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Takagi S, Hirata T, Agata K, Mochii M, Eguchi G, Fujisawa H. The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors. Neuron 1991; 7(2):295-307.
Fujisawa H, Takagi S, Hirata T. Growth-associated expression of a membrane protein, neuropilin, in Xenopus optic nerve fibers. Dev Neurosci 1995; 17(5-6):343-349.
Raper JA. Semaphorins and their receptors in vertebrates and invertebrates. Curr Opin Neurobiol 2000; 10(1):88-94.
Goodman CS, Kolodkin AL, Luo Y, Pueschel AW, Raper JA. Unified nomenclature for the semaphorins collapsins. Cell 1999; 97(5):551-552.
Luo Y, Raible D, Raper JA. Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell 1993; 75(2):217-227.
He Z, Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell 1997; 90(4):739-751.
Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD. Neuropilin is a semaphorin III receptor. Cell 1997; 90(4):753-762.
Giger RI, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL. Neuropilin2 is a receptor for semaphorin IV: Insight into the structural basis of receptor function and specificity. Neuron 1998; 21(5):1079-1092.
Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM. Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors. Nat Neurosci 1998; 1:487-493.
Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999; 13:9-22.
Robinson CJ, Stringer SE. The splice variants of vascular endothelial growth factor (VEGF) and their receptors. J Cell Sci 2001; I14(Pt 5):853-865.
Poltorak Z, Cohen T, Sivan R, Kandelis Y, Spira G, Vlodaysky I et al. VEGF145: A secreted VEGF form that binds to extracellular matrix. J Biol Chem 1997; 272:7151-7158.
Park JE, Keller GA, Ferrara N. Vascular endothelial growth factor (VEGF) isoforms-Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol Biol Cell 1993; 4:1317-1326.
Carmeliet P, Ng YS, Nuyens D, Theilmeier G, Brusselmans K, Cornelissen I et al. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nature Med 1999; 5(5):495-502.
Gitay-Goren H, Cohen T, Tessler S, Soker S, Gengrinovitch S, Rockwell P et al. Selective binding of VEGFI2I to one of the three VEGF receptors of vascular endothelial cells. J Biol Chem 1996; 271:5519-5523.
Soker S, Fidder H, Neufeld G, Klagsbrun M. Characterization of novel VEGF binding proteins associated with tumor cells that bind VEGF165 but not VEGF121. J Biol Chem 1996; 271:5761-5767.
Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform specific receptor for vascular endothelial growth factor. Cell 1998; 92:735-745.
Migdal M, Huppertz B, Tessler S, Comforti A, Shibuya M, Reich R et al. Neuropilin-I is a placenta growth factor-2 receptor. J Biol Chem 1998; 273(35):22272-22278.
Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G. Neuropilin-2 and Neuropilin-1 are receptors for 165-amino acid long form of vascular endothelial growth factor (VEGF) and of placenta growth factor-2, but only neuropilin-2 functions as a receptor for the 145 amino acid form of VEGF. J Biol Chem 2000; 275:18040-18045.
Soker S, Gollamudi-Payne S, Fidder H, Charmahelli H, Klagsbrun M. Inhibition of vascular endothelial growth factor (VEGF) induced endothelial cell proliferation by a peptide corresponding to the exon-7 encoded domain of VEGF165. J Biol Chem 1997; 272(50):31582-31588.
McDonnell JM. Surface plasmon resonance: towards an understanding of the mechanisms of biological molecular recognition. Curr Opin Chem Biol 2001; 5(5):572-577.
Fuh G, Garcia KC, De Vos AM. The interaction of Neuropilin-1 with vascular endothelial growth factor and its receptor Flt-1. J Biol Chem 2000; 275(35):26690-26695.
Whitaker GB, Limberg BJ, Rosenbaum JS. Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF165 and VEGF121. J Biol Chem 2001; 276(27):25520-25531.
Cai HB, Reed RR. Cloning and characterization of neuropilin-l-interacting protein: A PSD95/D1g/Z0-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1. J Neurosci 1999; 19(15):6519-6527.
Yamada Y, Takakura N, Yasue H, Ogawa H, Fujisawa H, Suda T. Exogenous clustered neuropilin 1 enhances vasculogenesis and angiogenesis. Blood 2001; 97(6):1671-1678.
Miao HQ, Lee P, Lin H, Soker S, Klagsbrun M. Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression. FASEB J 2000; 14(15):2532-2539.
Devries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 1992; 255:989-991.
Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H et al. Nucleotide sequence and expression of a novel human receptor type tyrosine kinase gene (fit) closely related to the fms family. Oncogene 1990; 5:519-524.
Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995; 376:66-70.
Hiratsuka S, Minowa O, Kuno J, Noda T, Shibuya M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci USA 1998; 95(16):9349-9354.
Giuzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G. Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes. J Biol Chem 2001; 276(22):18688-18694.
Bagnard D, Vaillant C, Khuth ST, Dufay N, Lohrum M, Puschel AW et al. Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor. J Neurosci 2001; 21(10):3332-3341.
Gagnon ML, Bielenberg DR, Gechtman Z, Miao HQ, Takashima S, Soker S et al. Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity. Proc Natl Acad Sci USA 2000; 97(6):2573-2578.
Miao HQ, Klagsbrun M. Neuropilin is a mediator of angiogenesis. Cancer Metastasis Rev 2000; 19(1-2):29-37.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Neufeld, G., Kessler, O., Herzog, Y. (2002). The Interaction of Neuropilin-1 and Neuropilin-2 with Tyrosine-Kinase Receptors for VEGF. In: Bagnard, D. (eds) Neuropilin: From Nervous System to Vascular and Tumor Biology. Advances in Experimental Medicine and Biology, vol 515. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0119-0_7
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0119-0_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4932-7
Online ISBN: 978-1-4615-0119-0
eBook Packages: Springer Book Archive