The Function of Neuropilin/Plexin Complexes

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 515)


Neuropilins bind the secreted class 3 semaphorins with high affinity but require a member of the plexin family to form receptors that are able to activate downstream signal transduction cascades. In this receptor complex neuropilins act as the ligand-binding subunit while plexins function as the signal-transducing subunit in the induction of cytoskeletal collapse by semaphorins. The cytoplasmic domain is highly conserved within the plexin family and interacts with Rho-like GTPases.


Growth Cone Cytoplasmic Domain Growth Cone Collapse Cell BioI Semaphorin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  1. 1.Institut für Allgemeine Zoologie und GenetikWestfälische Wilhelms-UniversitätMünsterGermany

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