Abstract
The neuropilin-1 (NRP1) and neuropilin-2 (NRP2) receptors can bind the class-3 semaphorin subfamily and the heparin-binding forms of vascular endothelial growth factor (VEGF) and placenta growth factor (P1GF). The functions of NRP 1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they promote angiogenesis and cell migration. In this chapter, we will present evidences indicating that neuropilin-1 is likely to mediate contacts between the dendritic cells and the T lymphocytes via homotypic interactions and is essential for the initiation of the primary immune response. These results emphasize the molecular similarities between the nervous and the immune systems and open new areas in the modulation of the immune response.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392:245–252.
Dustin ML, Cooper JA. The immunological synapse and the actin cytoskeleton: Molecular hardware for T cell signaling. Nature Immunol 2000; 1:23–29.
Lanzavecchia A, Sallusto F. Antigen decoding by T lymphocytes: From synapses to fate determination. Nature Immunol 2001; 2:487–492.
Langerhans P. Uber die nerven der menschlichen haut. Virchows Arch Path Anat 1868; 44:325–337.
Geissmann F, Prost C, Monnet JP et al. Transforming growth factor betal, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells. J Exp Med 1998; 187:961–966.
Chen H, He Z, Bagri A et al. Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins. Neuron 1998; 21:1283–1290
Tuttle R, Yano H, Chao MV et al. Neuropilin-1 and trk exist in a complex regulated by NGF. Soc Neurosci 2000; Abst 26:579.
Tordjman R, Ortega N, Coulombel L et al. Neuropilin-1 is expressed on bone marrow stromal cells: a novel interaction with hematopoietic cells? Blood 1999; 94:2301–2309
Castellani V, Chedotal A, Schachner M et al. Analysis of the LI-deficient mouse phenotype reveals cross-talk between Sema3A and LI signaling pathways in axonal guidance. Neuron 2000; 27:237–249.
Takahashi T, Fournier A, Nakamura F et al. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 1999; 99:59–69.
Driessens MH, Hu H, Nobes CD et al. XXXX Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho Curt Biol 2001; 11:339–344.
Al-Alwan MM, Rowden G, Lee TD et al. The dendritic cell cytoskeleton is critical for the formation of the immunological synapse. J Immunol 2001; 166:1452–1456
lezzi G, Scheidegger D, Lanzavecchia A. Migration and function of antigen-primed nonpolarized T lymphocytes in vivo. J Exp Med 2001; 193:987–993
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Romeo, PH., Lemarchandel, V., Tordjman, R. (2002). Neuropilin-1 in the Immune System. In: Bagnard, D. (eds) Neuropilin: From Nervous System to Vascular and Tumor Biology. Advances in Experimental Medicine and Biology, vol 515. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0119-0_4
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0119-0_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4932-7
Online ISBN: 978-1-4615-0119-0
eBook Packages: Springer Book Archive