Neuropilin-1 in the Immune System
The neuropilin-1 (NRP1) and neuropilin-2 (NRP2) receptors can bind the class-3 semaphorin subfamily and the heparin-binding forms of vascular endothelial growth factor (VEGF) and placenta growth factor (P1GF). The functions of NRP 1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they promote angiogenesis and cell migration. In this chapter, we will present evidences indicating that neuropilin-1 is likely to mediate contacts between the dendritic cells and the T lymphocytes via homotypic interactions and is essential for the initiation of the primary immune response. These results emphasize the molecular similarities between the nervous and the immune systems and open new areas in the modulation of the immune response.
Unable to display preview. Download preview PDF.
- 4.Langerhans P. Uber die nerven der menschlichen haut. Virchows Arch Path Anat 1868; 44:325–337.Google Scholar
- 5.Geissmann F, Prost C, Monnet JP et al. Transforming growth factor betal, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells. J Exp Med 1998; 187:961–966.PubMedCrossRefGoogle Scholar
- 7.Tuttle R, Yano H, Chao MV et al. Neuropilin-1 and trk exist in a complex regulated by NGF. Soc Neurosci 2000; Abst 26:579.Google Scholar
- 11.Driessens MH, Hu H, Nobes CD et al. XXXX Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho Curt Biol 2001; 11:339–344.Google Scholar