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Neuropilin and Class 3 Semaphorins in Nervous System Regeneration

  • Fred De Winter
  • Anthony J. G. D. Holtmaat
  • Joost Verhaagen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 515)

Abstract

Injury to the mature mammalian central nervous system (CNS) is often accompanied by permanent loss of function of the damaged neural circuits. The failure of injured CNS axons to regenerate is thought to be caused, in part, by neurite outgrowth inhibitory factors expressed in and around the lesion. These include several myelin associated inhibitors, proteoglycans, and tenascin-R. Recent studies have documented the presence of class 3 semaphorins in fibroblast-like meningeal cells present in the core of the neural scar formed following CNS injury. Class 3 semaphorins display neurite growth-inhibitory effects on growing axons during embryonic development. The induction of the expression of class 3 semaphorins in the neural scar and the persistent expression of their receptors, the neuropilins and plexins, by injured CNS neurons suggest that they contribute to the regenerative failure of CNS neurons. Neuropilins are also expressed in the neural scar in a subpopulation of meningeal fibroblast and in neurons in the vicinity of the scar. Semaphorin/neuropilin signaling might therefore also be important for cell migration, angiogenis and neuronal cell death in or around neural scars.

Keywords

Olfactory Epithelium Olfactory Receptor Neuron Adult Central Nervous System Main Olfactory Bulb Olfactory Axon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Fred De Winter
    • 1
  • Anthony J. G. D. Holtmaat
  • Joost Verhaagen
  1. 1.Netherlands Institute for Brain ResearchAmsterdamThe Netherlands

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