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From The Discovery of Neuropilin to the Determination of Its Adhesion Sites

  • Hajime Fujisawa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 515)

Abstract

Neuropilin (NRP) and plexin (Plex) that are now known to be semaphorin receptors were initially identified as antigens for monoclonal antibodies (MAbs) that bound to particular neuropiles and plexiform layers of theXenopustadpole optic tectum, several years before the discovery of semaphorin. The extracellular segment of the NRP protein is a mosaic of 3 functionally different protein motifs that are thought to be involved in molecular and/or cellular interactions, suggesting that NRP serves in a various cell-cell interaction by binding a variety of molecules. The first identified function of NRP was the cell adhesion activity; Cell reaggregation study using NRP-expressing cell lines revealed that NRP can mediate cell adhesion via heterophilic molecular interaction. Later, NRP was shown to bind semaphorins and vascular endothelial growth factor (VEGF). It was also shown that NRP makes receptor complexes with Plex to propagate semaphorin signals.

Keywords

Vascular Endothelial Growth Factor Retinal Ganglion Cell Plexiform Layer Optic Tectum Discoidin Domain Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Hajime Fujisawa
    • 1
  1. 1.Group of Developmental Neurobiology Division of Biological ScienceNagoya University Graduate School of ScienceChikusa-ku, NagoyaJapan

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