Cyclooxygenase-2 Inhibitors in Cancer Prevention and Treatment

  • Jaime L. Masferrer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 532)

Abstract

By inhibiting the cyclooxygenase (COX) enzyme, NSAIDs block the synthesis of prostaglandins, which are important mediators of multiple physiologic and pathophysiologic processes. There are 2 COX isoforms. COX-1 maintains physiologic processes, and its inhibition may be associated with undesirable effects. COX-2 is induced in response to growth factors, cytokines, and tumor promoters and is responsible for the therapeutic activity of NSAIDs. Epidemiologie, preclinical, and clinical evidence gathered over the last 15 years demonstrates that, in addition to their anti-inflammatory and analgesic properties, NSAIDs, particularly specific COX-2 inhibitors, such as celecoxib, also have a role in preventing tumor initiation and development.

Keywords

Toxicity Adenocarcinoma Adenoma Aspirin Prostaglandin 

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Jaime L. Masferrer
    • 1
  1. 1.Science Fellow, Pharmacia Corporation700 Chesterfield parkwaySt. LouisUSA

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