Abstract
Taurine chloramine (Tau-Cl) is produced through the actions of a halide-dependent myeloperoxidase system (MPO) that is associated primarily with polymorphonuclear leukocytes (PMN)1–3. Tau-Cl may be synthesized directly by MPO within the intracellular environment of PMN4, in part, because PMN intracellular taurine concentrations are in the range of 20 mM5. However, activated PMN secrete MPO and release it into the extracellular milieu upon death. Under extracellular conditions, where physiological taurine concentrations are usually low, MPO peroxidizes halide ions to produce HOCl/OCl-, which causes indiscriminate cellular damage to tissues at the site of inflammation. Taurine chemically reacts with HOCl/OCl- to rapidly form Tau-Cl, a more stable, less reactive and more selective oxidant than HOCl/OCl-. Administration of pharmacologic doses of taurine has been demonstrated to protect tissue from damage in several different paradigms where inflammation is likely to be elicited6.
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REFERENCES
Weiss, S.J., Klein, R., Slivka, A., and Wei, M., 1982, Chlorination of taurine by human neutrophils: evidence for hypochlorous acid generation.J. Clin. Invest.70: 598–607.
Weiss, S.J., Lampert, M.B., and Test, S.T., 1983, Long-lived oxidants generated by human neutrophils: characterization and bioactivity.Science222: 625–628.
Grisham, M.B., Jefferson, M.M., Melton, D.F., and Thomas E.L., 1984, Chlorination of endogeneous amines by isolated neutrophils.J. Biol. Chem.259: 10404–10413.
Marquez, L.A., and Dunford, H.B., 1994, Chlorination of taurine by myeloperoxidase: Kinetic evidence for an enzyme-bound intermediate.J. Biol. Chem.269: 7950–7956.
Learn, D.B., Fried, V.A., and Thomas, E.L., 1990, Taurine and hypotaurine contents of human leukocytes.J. Leukoc. Biol.48: 174–182.
Quinn, M.R., and Schuller-Levis,G.B., 1999, Taurine Chloramine, an Inhibitor of iNOS Expression and a Potential Modulator of Inflammation. InMolecular and Cellular Biology of Nitric Oxide(J. Laskin and D. Laskin, eds.), Marcel Dekker, Inc., New York, pp. 309–331.
Park, E., Quinn, M.R., Wright, C.E., and Schuller-Levis, G., 1993, Taurine chloramine inhibits the synthesis of nitric oxide and the release of tumor necrosis factor in activated RAW 264.7 cells.J. Leukoc. Biol.54: 119–124.
Marcinkiewicz, J., Grabowska, A., Bereta, J., and Stelmaszynska, T., 1995, Taurine chloramine, a product of activated neutrophils, inhibitsin vitrothe generation of nitric oxide and other macrophage inflammatory mediators.J. Leukoc. Biol.58: 667–674.
Galea, E., Feinstein, D.L., and Reis, D.L., 1992, Induction of calcium-independent nitric oxide synthase in primary rat glial cultures.Proc. Natl. Acad. Sci. USA89: 10945–10949.
O’Banion, M.K., Miller, J.C., Chang, J.W., Kaplan, M.D., and Coleman, P.D., 1996, Interleukin-113 induces prostaglandin G/H synthase 2 (cyclooxygenase-2) in primary murine astrocyte cultures.J. Neurochem.66: 2532–2540.
Ding, M., St. Pierre, B.A., Parkinson, J.F., Medberry, P., Wong, J.L., Rogers, N.E., Ignarro, L.J., and Merrill, J.E., 1997, Inducible nitric-oxide synthase and nitric oxide production in human fetal astrocytes and microglia.J. Biol. Chem.272: 11327–11335.
Akaike, T., Weihe, E., Schaefer, M., Fu, Z.F., Zheng, Y.M., Vogel, W., Schmidt, H., Koprowski, H., and Dietzschold, B., 1995, Effect of neurotropic virus infection on neuronal and inducible nitric oxide synthase activity in rat brain.J. Neuro. Virol.1: 118–125.
Koka, P., He, K., Zack, J.A., Kitchen, S., Peacock, W., Fried, I., Tran, T., Yashar, S.S., and Merill, J.E., 1995, Human immunodeficiency virus 1 envelope proteins induced interleukin 1, tumor necrosis factor a, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain.J. Exp. Med.182: 941–952.
Endoh, M., Maiese, K., and Wagner, J., 1994, Expression of the inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia.Brain Res.651: 92–100.
Nogawa, S., Zhang, F., Ross, M.E., and Iadecola, C., 1997, Cyclooxygenase-2 gene expression in neurons contributes to ischemic brain damage.J. Neurosci.17: 2746–2755.
Liu, Y., Tonna-DeMasi, M., Park, E., Schuller-Levis, G., and Quinn, M.R., 1998, Taurine chloramine inhibits production of nitric oxide and prostaglandin E2 in activated C6 glioma cells by suppressing inducible nitric oxide synthase and cyclooxygenase-2 expression.Molec. Brain Res.59: 189–195.
Liu, Y., Schuller-Levis, G., and Quinn, M.R., 1999, Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 production is inhibited by taurine chloramine in rat C6 glioma cells.Immunol. Leu.70: 9–14.
McCarthy, K.D., and de Villis, J., 1989, Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.J. Cell. Biol.85: 890–902.
Barua, M., Liu, Y., and Quinn, M.R., 2001, Taurine chloramine inhibits nitric oxide synthase and TNF-a gene expression in activated alveolar macrophages: Decreased NF-KB activation and IKB kinase activity.J. Immunol.167: 2275–2281.
Barnes, P.J., and Karin, M., 1997, Nuclear factor-KB, a pivotal transcription factor in chronic inflammatory diseases.N. Engl. J. Med.336: 1066–1071.
Karin, M., Ben-Neriah, Y., 2000, Phosphorylation meets ubiquitination: the control of NF-KB activity.Annu. Rev. Immunol.18: 621–663.
Ueda, A., Ishigatsubo, Y., Okubo, T., and Yoshimura, T., 1997, Transcriptional regulation of the human monocyte chemoattractant proten-1 gene.J. Biol. Chem.272: 31092–31099.
Newton, R., Kuitert, L.M.E., Bergmann, M., Adcock, I.M., and Barnes, P.J., 1997, Evidence for involvement of NF-KB in the transcriptional control of COX-2 gene expression by IL-10.Biochem. Biophys. Res. Commun.237: 28–32
Pahl, H.L., 1999, Activators and target genes of Rel/NF-xB transcription factors.Oncogene18: 6853–6866.
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Quinn, M.R., Barua, M., Liu, Y., Serban, V. (2003). Production of Inflammatory Mediators by Activated C6 Cells Is Attenuated by Taurine Chloramine Inhibition of NF-κB Activation. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine 5. Advances in Experimental Medicine and Biology, vol 526. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0077-3_45
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DOI: https://doi.org/10.1007/978-1-4615-0077-3_45
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