Abstract
There has recently been an increased demand for nutritional supplements and health drinks containing taurine. The Japanese diet also provides high levels of taurine. In addition, 60% of the over-the-counter (OTC) drugs classified as vitamin-mixture medication contain taurine (Figure 1). Because taurine intake is so high, there has been concern that it might interact with other drugs. A common form of drug-drug interaction involves the induction or inhibition of specific drug-metabolizing enzymes such as cytochrome P450 (CYP)1. However, little is known about the influence of taurine on the metabolism of clinically important drugs. The antibiotics rifampicin (RFP) is a strong CYP3A4 inducer in humans2. In the present study we examined whether taurine could affect the levels of CYP3A4 mRNA in the presence and absence of RFP.
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Takahashi, K. et al. (2003). Modulation of Taurine on CYP3A4 Induction by Rifampicin in a HepG2 Cell Line. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine 5. Advances in Experimental Medicine and Biology, vol 526. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0077-3_30
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DOI: https://doi.org/10.1007/978-1-4615-0077-3_30
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