Skip to main content
SpringerLink
Log in

Inhibitory Mechanism of Taurine on the Platelet-Derived Growth Factor BB-Mediated Proliferation in Aortic Vascular Smooth Muscle Cells

  • Chapter
Taurine 5

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 526))

Abstract

Platelet-derived growth factor-BB (PDGF-BB) is involved in the development of atherosclerosis in conjunction with the migration and the proliferation of vascular smooth muscle cells. PDGF-BB is produced by activated macrophages, smooth muscle cells and endothelial cells, or released from platelets, and its expression is increased in atherosclerotic lesions1,2. Thus, PDGF-BB is thought to play a critical role for the intimai thickening in the lesions of atherosclerosis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ross, R., 1993, The pathogenesis of atherosclerosis: a perspective for the 1990sNature362:801–809.

    Article  PubMed  CAS  Google Scholar 

  2. Heldin, C-H. and Westermark, B., 1999, Mechanism of action and in vivo role of platelet-derived growth factorPhysiol. Rev.79:1283–1316.

    PubMed  CAS  Google Scholar 

  3. Huxtable, R.J., 1992, Physiological actions of taurinePhysiol. Rev.72:101–163.

    PubMed  CAS  Google Scholar 

  4. Herrmann, R.G., 1959, Effect of taurine, glycine and f3-sitosterols on serum and tissue cholesterol in the rat and rabbitCirculation Res.7:224–227.

    Article  PubMed  CAS  Google Scholar 

  5. Mann, G.V., 1960, Experimental atherosclerosis: Effects of sulfur compounds on hypercholesteremia and growth in cysteine-deficient monkeysAm. J. Clin. Nutr.8:491–498.

    PubMed  CAS  Google Scholar 

  6. Yokogoshi, H., Mochizuki, H., Nanami, K., Hida, Y., Miyachi, F. and Oda, H., 1999, Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol dietJ. Nutt:129:1705–1712.

    CAS  Google Scholar 

  7. Takenaga, T., Imada, K. and Otomo, S., 2000, Hypolipidemic effect of taurine in golden Syrian hamstersAdv. Exp. Med. Biol.483:187–92.

    Article  PubMed  CAS  Google Scholar 

  8. Castelli, W.P., Garrison, R.J., Wilson, P.W.F., Abbott, R.D., Kalousdian, S. and Kannel, W.B., 1986, Incidence of coronary heart disease and lipoprotein cholesterol levels: the Framingham StudyJAMA256:2835–2838.

    Article  PubMed  CAS  Google Scholar 

  9. Austin, M.A., 1991, Plasma triglyceride and coronary heart diseaseArterioscler. Thromb.11:2–14.

    Google Scholar 

  10. Petty, M.A., Kintz, J. and DiFrancesco, G.F., 1990, The effect of taurine on atherosclerosis development in cholesterol-fed rabbitsEur.J.Pharmacol.180:119–127.

    Article  PubMed  CAS  Google Scholar 

  11. Murakami, S., Kondo, Y., Sakurai, T., Kitajima, H. and Nagate, T., 2002, Taurine suppresses development of atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbitstherosclerosis163:79–87.

    Article  CAS  Google Scholar 

  12. Imada, K., Takenaga, T., Otomo, S., Hosokawa, Y. and Totani, M., 2000, Taurine attenuates the induction of immediate-early gene expression by PDGF-BBAdv. Exp. Med. Biol.483:589–594.

    Article  PubMed  CAS  Google Scholar 

  13. Thommes, K.B., Hoppe, J., Vetter, H. and Sachinidis, A., 1996, The synergistic effect of PDGF-AA and IGF-1 on VSMC proliferation might be explained by the differential activation of their intracellular signaling pathways.Exp. Cell. Res.226:59–66.

    Article  PubMed  CAS  Google Scholar 

  14. Chomczynski, P. and Sacchi, N., 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extractionAnal. Biochem.162:156–159.

    Article  PubMed  CAS  Google Scholar 

  15. Firulli, A.B., Han, D., Kelly-Roloff, L., Koteliansky, V.E., Schwartz, S.M., Olson, E.N. and Miano, J.M., 1998, A comparative molecular analysis of four rat smooth muscle cell linesIn Vitro Cell Dev. Biol. Anim.34:217–226.

    Article  PubMed  CAS  Google Scholar 

  16. Kanayama, A., Inoue, J., Sugita-Konishi, Y., Shimizu, M. and Miyamoto, Y., 2002, Oxidation of I-kappa B alpha at methionine 45 is one cause of taurine chloramine-induced inhibition of NF-kappa B activation.J. Biol. Chem.277:24049–24056.

    Article  PubMed  CAS  Google Scholar 

  17. Takahashi, K., Azuma, M., Taira, K., Baba, A., Yamamoto, I., Schaffer, S.W. and Azuma, J., 1997, Effect of taurine on angiotensin II-induced hypertrophy of neonatal rat cardiac cells.J. Cardiovasc. Pharmacol.30:725–730.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pharmacological Evaluation Laboratory, Taisho Pharmaceutical, Co.Ltd, Japan

    Keisuke Imada, Kazumi Nakano, Takaaki Takenaga & Michio Kurachi

  2. Department of Food and Health Sciences, Jissen Women’s University, Japan

    Yu Hosokawa

  3. Department of Biochemistry, Shimane Medical University, Japan

    Masaharu Terashima, Toshifumi Mitani & Yoshinori Tanigawa

Authors
  1. Keisuke Imada
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yu Hosokawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masaharu Terashima
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Toshifumi Mitani
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yoshinori Tanigawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kazumi Nakano
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Takaaki Takenaga
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Michio Kurachi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Health Sciences Center, Texas Tech University, Lubbock, Texas, USA

    John B. Lombardini

  2. School of Medicine, University of South Alabama, Mobile, Alabama, USA

    Stephen W. Schaffer

  3. Osaka University, Osaka, Japan

    Junichi Azuma

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media New York

About this chapter

Cite this chapter

Imada, K. et al. (2003). Inhibitory Mechanism of Taurine on the Platelet-Derived Growth Factor BB-Mediated Proliferation in Aortic Vascular Smooth Muscle Cells. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine 5. Advances in Experimental Medicine and Biology, vol 526. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0077-3_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-0077-3_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4913-6

  • Online ISBN: 978-1-4615-0077-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation