Abstract
The p53 tumor suppressor gene functions as a cell cycle checkpoint, blocking cell division in the G1 phase to allow repair of damaged DNA or even triggering apoptosis in cells that have defective genomes 1. Numerous stimuli trigger increases in the level of p53, including DNA-damaging drugs, ionizing radiation, ultraviolet light, and hypoxia 2–5. MCF-7, a human breast cancer estrogen receptor-positive (ER+) cell line, expresses a high level of wild-type p53, which is up-regulated by 17-ß-estradiol (E2) 6. However, p53 function is largely inactivated in MCF-7 cells, caused by misallocation of p53 from nuclei to cytosol 7, which may result in the altered expression of certain p53 target genes. Studies have shown that the taurine transporter gene (TauT) is a putative target of p53 8, and that mutation of TauT results in severe and progressive retinal degeneration, a small brain, and shrunken kidneys 9. In the present study, we show that TauT is up-regulated by p53 and E2 in MCF-7 human breast cancer cells in a manner that appears to be mediated by estrogen receptor α (ERα).
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Han, X., Patters, A.B., Chesney, R.W. (2003). Transactivation of TauT by p53 in MCF-7 Cells. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine 5. Advances in Experimental Medicine and Biology, vol 526. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0077-3_18
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DOI: https://doi.org/10.1007/978-1-4615-0077-3_18
Publisher Name: Springer, Boston, MA
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