Abstract
Taurine (2-ethaneaminosulfonic acid, +NH3CH2CH2SO3) is an endogenous amino acid which functions as a modulator of transmembrane calcium transport, an osmoregulator and, putatively a free radical scavenger1. In utero, taurine deficiency causes an abnormal development of brain, retina, kidney, and abnormal function of the myocardium, where taurine plays an important role in intracellular calcium homeostasis in the cardiomyocytes2–4.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Chesney, R.W., and Budreau, A., 1993, Efflux of taurine from renal brush border membrane vesicles: Is it adaptively regulated?. Pediatr. Nephrol. 7: 35–40.
Chesney, R.W., Gusowski, N., and Dabbagh, S., 1985, Renal cortex taurine content regulates renal adaptive response to altered dietary intake of sulfur amino acids. J. Clin. Invest. 76: 2213–2221.
Chesney, R.W., Gusowski, N., and Freidman, A.L., 1983, Renal adaptation to altered amino acid intake occurs at the luminal brush border membrane. Kidney Int. 24: 588–594.
Chesney, R.W., Helms, R.A., Christensen, M., Budreau, A.M., Han, X., and Sturman, J.A., 1998, An updated view of the value of taurine in infant nutrition. In Advances in Pediatrics,edited by Barnes La, pp. 179–193.
Uchida, S., Kwon, H.M., Yamauchi, A., Preston, A.S., Marumo, F., and Handler, J.S., 1992, Molecular cloning of the cDNA for an MDCK cell Nat-and CF-dependent taurine transporter that is regulated by hypertonicity. Proc. Natl. Acad. Sei. USA 89: 8230–8234.
Smith, K.E., Borden, L.A., Wang, C.D., Hartig, P.R., Branchek, T.A., and Weinshank, R.L., 1992, Cloning and expression of a high affinity taurine transporter from rat brain. Mol. Pharmacol. 42: 563–569.
Liu, Q.R., Lopez-Corcuera, B., Nelson, H., Mandiyan, S., and Nelson, N., 1992, Cloning and expression of a cDNA encoding the transporter of taurine and 13-alanine in mouse brain. Proc. Natl. Acad. Sci. USA 89: 12145–12149.
Vinnakota, S., Qian, X., Egal, H., Sarthy, V., and Sarkar, H.K., 1997, Molecular characterization and in situ localization of a mouse retinal taurine transporter. J. Neurochem. 69: 2238–2250.
Han, W., Budreau, A.M., and Chesney, R.W., 1998, Molecular cloning and functional expression of an LLC-PK1 cell taurine transporter that is adaptively regulated by taurine. Adv. Exp. Med. Biol. 442: 261–268.
Jhiang, S.M., Fithian, L., Smanik, P., McGill, J., Tong, Q., and Mazzaferri, E.L., 1993, Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells. FEBS Lett. 318: 139–144.
Ramamoorthy, S., Leibach, F.H., Mahesh, V.B., Han, H., Yang-Feng, T., Blakely, R.D., and Ganapathy, V., 1994, Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Biochem. J. 300: 893–900.
Miyamoto, Y., Lion, G.I., and Sprinkle, T.J., 1996, Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium. Curr. Eye Res. 15: 345–349.
Takeuchi, K., Toyohara, H., and Sakaguchi, M., 2000, A hyperosmotic stress-induced mRNA of carp cell encodes Na+- and Cl-dependent high affinity taurine transporter. Biochim. Biophys. Acta. 1464: 219–230.
Han, X., Budreau, A.M., and Chesney, R.W., 1999, Ser-322 is a critical site for PKC regulation of the MDCK cell taurine transporter (pNCT). J. Am. Soc. Nephrol. 10: 1874–1879.
Tebele, N., Skilton, R.A., Katende, J., Wells, C.W., Nene, V., McElwain, T., Morzaria, S.P., and Musoke, A.J., 2000, Cloning, characterization, and expression of a 200-kilodalton diagnostic antigen of Babesia bigemina. J. Clin. Microbiol. 38(6): 2240–2247.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
An, H.S., Han, H.C., Park, T., Park, K.K., Kim, H.W. (2003). Cloning of Human Intestinal Taurine Transporter and Production of Polyclonal Antibody. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine 5. Advances in Experimental Medicine and Biology, vol 526. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0077-3_17
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0077-3_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4913-6
Online ISBN: 978-1-4615-0077-3
eBook Packages: Springer Book Archive