Taurine 5 pp 107-114 | Cite as

Taurine and Cellular Volume Regulation in the Hippocampus

  • James E. Olson
  • Norman R. Kreisman
  • Jenny Lim
  • Beth Hoffman-Kuczynski
  • Dana Schelble
  • James Leasure
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 526)


Taurine is an important osmolyte used for volume regulation in a variety of cell culture systems, including neurons and astroglial cells1–2. Taurine efflux from brain slices and taurine mobilization to the extracellular space of the intact brain appears during exposure to hypoosmotic conditions also suggesting this amino acid is used for brain volume regulation3–4. Taurine contents of isolated cells and brain slice preparations decrease within minutes of exposure to hypoosmolality and other conditions which cause cell swelling. However, little change is observed in brain taurine content of animals exposed to hypoosmotic hyponatremia for several hours5*#x2013;6. Thus, taurine may be redistributed between different cell types of the brain in response to cell swelling. To obtain a better understanding of the role taurine plays in volume regulation of the brain in situ, we examined taurine contents and cellular volume in slices of rat hippocampus during hypoosmotic exposure.


Hippocampal Slice Regulatory Volume Decrease Pyramidal Cell Layer Taurine Release Taurine Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • James E. Olson
    • 1
    • 2
  • Norman R. Kreisman
    • 3
  • Jenny Lim
    • 1
  • Beth Hoffman-Kuczynski
    • 1
  • Dana Schelble
    • 1
  • James Leasure
    • 1
  1. 1.Department of Emergency MedicineWright State University School of MedicineDaytonUSA
  2. 2.Department of Physiology and BiophysicsWright State University School of MedicineDaytonUSA
  3. 3.Department of PhysiologyTulane University Medical SchoolNew OrleansUSA

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