Abstract
Taurine (2-aminoethanesulfonic acid) is a normal constituent of the human diet and is found in animal food sources. Taurine has many biological functions including bile acid conjugation, osmoregulation, membrane protection, antioxidant defense, and regulation of cellular calcium homeostasis1–3. It has been suggested that taurine might serve as a physiological regulator of insulin secretion and plasma glucose levels4. It has been reported that taurine acts as a potent antioxidant and exhibits anti-diabetic activity in streptozotocin-induced diabetes mellitus5–6. Recently an immunohistochemical study showed that taurine protects pancreatic β-cells of rats against destruction by streptozotocin injection in a dose-dependent way7. Also, it has been reported that the plasma and platelet taurine content are reduced in subjects with insulin-dependent diabetes mellitus, although this defect can be reversed by taurine supplementation8. Therefore, the purpose of this study was to investigate the effect of dietary taurine supplementation on the plasma and urinary free amino acid content in diabetic rats.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Huxtable, R.J., 1992, Physiological Action of Taurine. Physiological Reviews 72(1): 101–163.
Redmond, H.P., Stepleton, P.P., Neary, P., Bouchier-Hayes, D., 1998, Immunoutrition: The role of taurine. Nutriion 14:599–604.
Monte, M.J., El-Mir, M.Y., Saninz, GR., Bravo, P., Marin, J.J., 1997, Bile acid secretion during synchronized rat liver regeneration. Biochim Biophys Acta 1362: 56–66.
Tokanaga, H., Yoned, Y., Kuriyama, K, 1979, Protective action of taurine against streptozotocin-induced hyperglycemia. Biochem Pharmacol 28: 2807–2811.
You, J.S., Chang, K.J., 1998, Effects of taurine supplementation on lipid peroxidation, blood glucose and blood lipid metabolism in streptozotocin-induced diabetic rats. Adv Exp Med Bio! 442: 163–168.
Lim, E., Park, S., Kim, H., 1998, Effect of taurine supplementation on the lipid peroxide formation and the activities of glutathione-related enzymes in the liver and islet of type and type 11 diabetic model mice. Adv Exp Med Biol 442: 99–103.
Chang, K.J., Kwon, W., 2000, Immunohistochemical localization of insulin in pancreatic beta-cells of taurine-supplemented or taurine-depleted diabetic rats. Adv Exp Med Biol 483: 579–587.
Franconi, F., Bennardini, F., Mattana, A., 1995, Plasma and platelet taurine are reduced in subject with insulin-dependent diabetes mellitus; Effect of taurine supplementation. Am J Clin Nutr 61: 1115–1119.
Sauberlich, H.E., 1961, Studies on the toxiology and antagonism of amino acid for weanling rats. J Nutr 75: 61–72.
Fridewald, W.T., Lavy, R.I., Fredricson, D.S., 1972, Estimation of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499–502.
Folch, J., Lees, M., Slane-Stanly, G.H., 1957, A simple method for the isolation and purification of total lipids from animal tissue. J Biochem 226: 497–509.
McNeill, J.H., Delgatty, H.L, Battell, M.L, 1991, Insulinlike effects of sodium selenate in streptozocin-induced diabetic rats. Diabetes 40(12): 1675–1678.
Malabu, U.H., Dryden, S., McCarthy, H.D., Kilpatrick, A., Williams, G, 1994, Effects of chronic vanadate administration in the STZ-induced diabetic rat. The antihyperglycemic action of vanadate is attributable entirely to its suppression of feeding. Diabetes 43: 9–5.
Kahn, C.R., 1985, The molecular mechanism of insulin action. Ann Rev Med 36: 429–433.
Tambor1ane, W.V., Sherwin, R.S., Genel, M., Felig, P., 1979, XRestoration of normal lipid and aminoacid metabolism in diabetic patients treated with a portable insulin-infusion pump. Lancet 16: 1258–1261.
Goodman, H.O., Shihabi, Z.K., 1990, Supplemental taurine in diabetic rats: effects on plasma glucose and triglycerides. Biochem Med Metab Bio! 43(1): 1–9.
Ressin, K., Gaull, GE., Jarvenpaa, A.L., 1983, Feeding the low-birth-weight infant: Effect of taurine and cholesterol supplementation on amino acids and cholesterol. Pediatrics 71 179–186.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
Lee, YM., Choi, M.J., Chang, K.J. (2003). The Effect of Dietary Taurine Supplementation on Plasma and Urinary Free Amino Acid Concentrations in Diabetic Rats. In: Lombardini, J.B., Schaffer, S.W., Azuma, J. (eds) Taurine 5. Advances in Experimental Medicine and Biology, vol 526. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0077-3_10
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0077-3_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4913-6
Online ISBN: 978-1-4615-0077-3
eBook Packages: Springer Book Archive