Abstract
A new method to non-invasively measure the absolute tissue oxygen saturation (SO2) and arterial oxygen saturation (fdSaO2) by frequency-domain spectroscopy is described. This method is based on the quantitative measurement of the tissue absorption spectrum, which is used to determine global SO2. From the amplitude of absorption changes caused by arterial pulsation oscillations, in the range of 633-841 nm, the fdSaO2 can be calculated. During deoxygenation (air/N2 mixture) experiments, we measured the fdSaO2 and SO2 on the forehead of three healthy volunteers and compared them to the arterial oxygen saturation measured by conventional pulse oximetry (poSaO2) on the finger. fdSaO2 and poSaO2 agree very well (mean difference: -1.2±2.6%). Changes in SO2 were systematically smaller than in fdSaO2 or poSaO2 probably due to autoregulation. The measurements with 4 and 8 wavelengths had comparable quality.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fantini S, Franceschini-Fantini MA, Maier JS, Walker SA, Barbieri B, Gratton E. Frequency-domain multichannel optical detector for noninvasive tissue spectroscopy and oximetry. Opt Eng 1995;34:32–42.
Miwa M, Ueda Y, Chance B. Development of time-resolved spectroscopy system for quantitative noninvasive tissue measurement. SPIE 1995;2389:142–149.
Liu H, Chance B, Hielscher AH, Jacques SL, Tittel FK. Influence of blood vessels on the measurement of hemoglobin oxygenation as determined by time-resolved reflectance spectroscopy. Med Phys I995;22:1209–1217.
Kohl M, Nolte C, Heekeren HR, Horst S, Scholz U, Obrig H, Villringer A. Changes in cytochrome-oxidase oxidation in the occipital cortex during visual simulation: improvement in sensitivity by the determination of the wavelength dependence of the differential pathlength. SPIE 1998;3194:18–27.
Mendelson Y. Pulse oximetry: theory and applications for noninvasive monitoring. Clin Chem 1992;38:1601–1607.
Webb RK, Ralston AC, Runciman WB. Potential errors in pulse oximetry. II. Effects of changes in saturation and signal quality. Anaesthesia 1991;46:207–212.
Franceschini MA, Gratton E, Fantini S. Noninvasive optical method of measuring tissue and arterial saturation: an application to absolute pulse oximetry of the brain. Opt Lett 1999;24:1–3.
Franceschini MA, Wallace D, Barbieri B, Fantini S, Mantulin WW, Pratesi S, Donzelli GP, Gratton E. Optical study of the skeletal muscle during exercise with a second generation frequency-domain tissue oximeter. SPIE 1997;2979:807–814.
Hueber DM, Fantini S, Cerussi AE, Barbieri B. New optical probe design for absolute (self-calibrating) NIR tissue hemoglobin measurements. SPIE 1999;3597:618–631.
Fantini S, Franceschini MA, Gratton E. Semi-infinite-geometry boundary problem for light migration in highly scattering media: a frequency-domain study in the diffusion approximation. J Opt Soc Am B 1994;11:2128–2138.
Delpy DT, Cope M, van der Zee P, Arridge S, Wray S, Wyatt J. Estimation of optical pathlength through tissue from direct time of flight measurement. Phys Med Biol 1988;33:1433–1442.
Wray S, Cope M, Delpy DT, Wyatt JS, Reynolds EO. Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation. Biochim Biophys Acta 1988;933:184–192.
Villringer K, Minoshima S, Hock C, Obrig H, Ziegler S, Dirnagl U, Schwaiger M,Villringer A. Assessment of local brain activation. Adv Exp Med Biol 1997;413:149–153.
Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;1(8476):307–10.
Hudetz AG. Regulation of oxygen supply in the cerebral circulation. Adv Exp Med Biol 1997;428:513–520.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
Wolf, M. et al. (2003). Absolute Frequency-Domain Pulse Oximetry of the Brain: Methodology and Measurements. In: Dunn, J.F., Swartz, H.M. (eds) Oxygen Transport to Tissue XXIV. Advances in Experimental Medicine and Biology, vol 530. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0075-9_7
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0075-9_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4912-9
Online ISBN: 978-1-4615-0075-9
eBook Packages: Springer Book Archive