Abstract
Heat-up tilting manoeuvre from 0 to 60 degrees induces oxygenated and deoxygenated haemoglobin concentration changes in the human gastrocnemius. These changes, measured by NIRS, can only be partially explained by the blood volume displacement due to the gravitational force. In the present study it is demontrated, by a dye dilution technique (indocyanine green), that a reduction in blood flow (venous-arteriolar and/or spinal reflex) is responsible of the limited oxyhaemoglobin concentration increase observed when going from 0 (2.54 ± 0.48 blood flow in arbitrary units, a.u.) to 60 (1.46 ± 0.55 a.u.) degrees. The proposed technique is potentially applicable to the detection of specific pathological aspects of microcirculation, such as arterial occlusion in the leg, diabetes mellitus, and congestive heart failure, where the venous-arteriolar reflex may be affected.
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References
Binzoni T, Quaresima V, Ferrari M, Hiltbrand E, Cerretelli P. Human calf microvascular compliance measured by near infrared spectroscopy. J Appl Physiol 2000;369–372.
Garskell P, Burton AC. Local posture vasomotor reflexes arising from the limb veins. Circ Res 1953;1:27–39.
Murray-Kinsman J, Moore JV, Hamilton WF. Studies on the circulation. I. Injection method: physical and mathematical considerations. Am J Physiol 1929;89:322–330.
Cope M, Delpy DT, Wray S, Wyatt JS, Reynolds EOR. A CCD spectrometer to quantitate the concentration of chromophores in living tissue utilising the absorption peak of water at 975 nm. Adv Exp Med & Biol 1989;248:33–40.
Duncan A, Meek JH, Clemence M, Elwell CE, Tyszczuk L, Cope M, Delpy DT. Optical pathlength measurements on adult head, calf and forearm and head of newborn infant using phase resolved optical spectroscopy. Phys. Med. Biol. 1995;40:295–304.
Lassen NA, Perl W. Tracer kinetics methods in medical physiology. Raven Press, New York, 1979.
Henriksen O. Sympathetic reflex control of blood flow in human peripheral tissues. Acta Physiol Scand 1991;143 (Suppl. 603):33–39.
Henriksen O. Orthostatic changes of blood flow in subcutaneous tissue in patients with arterial insufficiency of the legs. Scand J Clin Lab Invest 1974;34:103–109.
Agerskov K, Henriksen O, Tønnesen KH, Lassen NA. Constriction of collateral arteries induced by head-up til in patients with occlusive arterial disease of legs. Cardiovasc Res 1981;15:675–679.
Hilsted J. Decreased sympathetic vasomotor tone in diabetic othostatic hypotension. Diabetes 1979;28:970–973.
Kassis E, Amtorp O, Skagen K. Sympathetic reflex control of subcutaneous blood flow in patients with congestive heart failure. Clin Sci 1986;70:523–522.
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Binzoni, T., Ngo, L., Girardis, M., Springett, R., Terrier, F., Delpy, D. (2003). Venous-Arteriolar Reflex in Human Gastrocnemius Studied by NIRS. In: Dunn, J.F., Swartz, H.M. (eds) Oxygen Transport to Tissue XXIV. Advances in Experimental Medicine and Biology, vol 530. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0075-9_44
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DOI: https://doi.org/10.1007/978-1-4615-0075-9_44
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