Abstract
Perfluorochemical (PFC) emulsions have been in development as intravenous oxygen carriers for a number of years and many publications have dealt with their oxygen transport characteristics in both experimental models and in clinical trials. Though it has been stressed on numerous occasions that PFCs deliver oxygen to the tissues in very different ways to those by which Hemoglobin (Hb) releases oxygen (O2), no serious attempts have been made to correlate the oxygen delivery capacity of PFCs to those of Hb. This paper presents theoretical ways in which this can be done and demonstrates that a 2.7 g/kg dose of PFC is approximately equivalent to 4 g/dL [Hb]. Clinical trial planning is discussed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Gregory IC. The oxygen and carbon monoxide capacities of foetal and adult blood. J Physiol 1974;326:625–634.
Braunitzer G. Molekulaire struktur von haemoglobine. Nova Acta Acad Caesar Leop Carat 1963;26:471.
Prys-Roberts C, Foex P, Hahn CEW. Calculation of Blood PO2. Anesthesiology 1971;34:581–582.
Geyer RP, Monroe RG, Taylor K. Survival of rats totally perfused with a fluorocarbon-detergent preparation. In: Normal JC Ed. Organ perfusion and preservation. New York:Appleton Century Crofts 1986;85–96.
Kelman GR. Digital subroutine for the conversion of oxygen tension into saturation. J Appl Physiol 1966;21:1375–76.
Faithfull NS, Rhoades GE, Keipert PE, et al. A program to calculate mixed venous oxygen tension - A guide to transfusion? Adv Exp Med Biol 1994;361:41–9.
Habler OP, Keen MS, Rutter JW, et al. Hemodilution and intravenous perflubron emulsion as an alternative to blood transfusion: Effects on tissue oxygenation during profound hemodilution in anesthetized dogs. Transfusion 1998;38:145–155.
Batra S, Peters BP, Symonds JD, et al. Perflubron emulsion increases tissue oxygenation in a canine model of hemodilution. Artif Cells, Blood Subs and Immob Technol 1996;24:307.
Weiskopf RB. Mathematical analysis of isovolemic hemodilution indicates that it can decrease the need for allogeneic blood transfusion. Transfusion 1995;35:37–41.
Nadler SB, Hidalgo JU, Bloch T. Prediction of blood volume in normal human adults. Surgery 1962;51:224–232.
Spahn DR, Waschke K, Standl T, et al. Use of perflubron emulsion to decrease allogeneic blood transfusion in high-blood-loss non-cardiac surgery: results of a European Phase 3 study. Anesthes 2002;97. In Press.
Turnan KJ. Tissue oxygen delivery. Anesthesiology Clinics of North America 1990;8:451–69.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
Faithfull, N.S. (2003). The Concept of Hemoglobin Equivalency of Perfluorochemical Emulsions. In: Dunn, J.F., Swartz, H.M. (eds) Oxygen Transport to Tissue XXIV. Advances in Experimental Medicine and Biology, vol 530. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0075-9_26
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0075-9_26
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4912-9
Online ISBN: 978-1-4615-0075-9
eBook Packages: Springer Book Archive