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Oxygen Transport to Tissue XXIV pp 225–236Cite as

Tumor Oxygen Dynamics: Comparison of 19F MR EPI and Frequency Domain NIR Spectroscopy

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 530))

Abstract

Oxygen plays a key role in tumor therapy and may be related to tumordevelopment: e.g., angiogenesis and metastasis. Using noninvasive techniques to accurately measure tumor oxygenation could assist in developing novel therapies. Here, we have used the FREDOM (Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping) approach based on hexafluorobenzene (HFB) to monitor tissue oxygen tension (pO2) of rat breast and prostate tumors and compared the results with changes in tumor vascular hemoglobin saturation (sO2) and concentration observed using a new dual wavelength homodyne near-infrared (NIR) system. The dynamic changes in pO2 and sO2 were assessed while rats were breathing various gases. NIR showed significant changes in vascular oxygenation accompanying respiratory interventions. 19F MR-EPI also showed significant changes in tissue pO2 and revealed considerable regional heterogeneity in both absolute values and rate of change accompanying interventions. Generally, changes in vascular sO2 preceded tissue pO2, particularly for smaller tumors.

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Abbreviations

NIR:

Near infrared

EPI:

Echo Planar Imaging

HFB:

Hexafluorobenzene

FREDOM:

Fluorocarbon Relaxometry using Echo phanar imaging for Dynamic Oxygen Mapping

References

  1. Pötgens AJG, Westphal HR, de Waal RMW, Ruiter DJ. The Role of Vascular Permeability Factor and Basic Fibroblast Growth Factor in Tumor Angiogenesis. Biol Chem Hopper-Seyler, 1995; 376:57–70.

    Google Scholar 

  2. Gray LH, Conger AD, Ebert M, Hornsey S, Scott OCA. The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy. Br J Radiol I953;26:638–648.

    Article  Google Scholar 

  3. Brown J.M, Giaccia AJ. Tumor Hypoxia: the Picture has Changed in the 1990s. Int J Radiat Biol 1994; 65:95–102.

    Article  PubMed  CAS  Google Scholar 

  4. Stratford I, Adams G, Bremmer J, Cole S, et al. Manipulation and Exploitation of the Tumor Environment for Therapeutic Benefit. Int J Radiat Biol 1994; 85–94.

    Google Scholar 

  5. Höckel M, Schlenger K, Aral B, Mitze M, Schäffer U, Vaupel P. Association between Tumor Hypoxia and Malignant Progression in Advanced Cancer of the Uterine Cervix. Cancer Res 1996;56:4509–4515.

    PubMed  Google Scholar 

  6. Fyles AW, Milosevic M, Wong R, Kavanagh MC, Pintile M, Sun A, Chapman W, Levin W, Manchul L, Keane TJ, Hill RP. Oxygenation Predicts Radiation Response and Survival in Patients with Cervix Cancer. Radiother Oncol 1998;48:149–56.

    Article  PubMed  CAS  Google Scholar 

  7. Mason R.P. Non-invasive Physiology: 19F NMR of Perfluorocarbons. Artif Cells Blood Sub.lmmob Biotechnol.1994;22:1141–1153.

    Article  CAS  Google Scholar 

  8. Mason RP, Rodbumrung W, Antich PP. Hexafluorobenzene: a Sensitive 19F NMR Indicator of Tumor Oxygenation. NMR in Biomed 1996; 9:125–134.

    Article  CAS  Google Scholar 

  9. Yunsong Y, Liu H, Li X, Chance B. Low-Cost Frequency-Domain Photon Migration Instrument for Tissue Spectroscopy, Oximetry, and Imaging. Opt Eng I997;36:1562–1569.

    Google Scholar 

  10. Hahn EW, Peschke P, Mason RP, Babcock EE, Antich PP. Isolated Tumor Growth in a Surgically Formed Skin Pedicle in the Rat: A New Tumor Model for NMR Studies. Magn Reson Imaging. 1993;11:1007–1017.

    Article  PubMed  CAS  Google Scholar 

  11. Le D, Mason RP, Hunjan S, Constantinescu A, Barker BR, Antich PP. Regional Tumor Oxygen Dynamics: 19F PBSR EPI of Hexafluorobenzene. Magn Reson Imaging 1997;15:971–981.

    Article  PubMed  CAS  Google Scholar 

  12. Brizel DM, Lin S, Johnson JL, Brooks J, Dewhirst MW, Piantadosi CA. The Mechanisms by Which Hyperbaric Oxygen and Carbogen Improve Tumour Oxygenation. Br J of Cancer 1995;72:1120–1124.

    Article  CAS  Google Scholar 

  13. Lanzen JL, Braun RD, Ong AL., Dewhirst MW. Variability in Blood Flow and p02 in Tumors in Response to Carbogen Breathing. Int J Radiat Oncol Biol Phys 1998; 42:855–859.

    Article  PubMed  CAS  Google Scholar 

  14. van der Sanden BPJ, Heerschap A, Simonetti AW, Rijken PFJW, Peters HPW, Stiiben G, van der Kogel AJ. Characterization and Validation of Noninvasive Oxygen Tension Measurements in Human Glioma Xenografts by 19F-MR Relaxometry. Int J Radiat Oncol Biol Phys 1999;44:649–658.

    Article  PubMed  Google Scholar 

  15. Mason RP, Constantinescu A, Hunjan S, Le D, Hahn EW, Blum C, Antich PP, Peschke P. Regional Tumor Oxygenation and Measurement of Dynamic Changes. Radiat Res 1999;152:239–249.

    Article  PubMed  CAS  Google Scholar 

  16. Dewhirst MW, Ong ET, Braun RD, Smith B, Klitzman B, Evans SM Wilson D, Quantification of Longitudinal Tissue p02 Gradients in Window Chamber Tumours: Impact on Tumour Hypoxia. Br J of Cancer 1999;79:1717–1722.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Joint Graduate Program in Biomedical Engineering, UT Southwestern Medical Center, Dallas, TX, 75390, USA

    Yulin Song, Kate L. Worden, Xin Jiang & Hanli Liu

  2. Department of Radiology, UT Southwestern Medical Center, Dallas, TX, 75390, USA

    Yulin Song, Dawen Zhao, Anca Constantinescu & Ralph P. Mason

Authors
  1. Yulin Song
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  2. Kate L. Worden
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  3. Xin Jiang
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  4. Dawen Zhao
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  5. Anca Constantinescu
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  6. Hanli Liu
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  7. Ralph P. Mason
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Editor information

Editors and Affiliations

  1. Dartmouth Medical School, Hanover, New Hampshire, USA

    Jeffrey F. Dunn  & Harold M. Swartz  & 

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Song, Y. et al. (2003). Tumor Oxygen Dynamics: Comparison of 19F MR EPI and Frequency Domain NIR Spectroscopy. In: Dunn, J.F., Swartz, H.M. (eds) Oxygen Transport to Tissue XXIV. Advances in Experimental Medicine and Biology, vol 530. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0075-9_22

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  • DOI: https://doi.org/10.1007/978-1-4615-0075-9_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4912-9

  • Online ISBN: 978-1-4615-0075-9

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