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Glycobiology and Medicine pp 107–124Cite as

Lectin Domains on Cytokines

  • Conference paper

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 535))

Abstract

There is increasing evidence that carbohydrate-binding proteins (lectins) are widespread in mammals (Kilpatrick, 2002), and especially in cells of the immune system. Several tenths calcium-dependent lectins (C-type lectins; Dodd and Drickamer, 2001; Drickamer, 1997) have been identified each endowed with a different carbohydrate-binding specificity. For example, L-selectin (Foxall et al., 1992; Lasky, 1992) recognizes the 6′-sulphated sialyl-Lewisx epitope. Mannan-binding lectins constitute a family of related calcium-dependent lectins with important implications in the field of human pathology (Kawasaki, 1999; Kilpatrick, 2002). Likewise the calcium-independent lectins comprise the lactose-binding galectins (Cooper, 2002), the I-type lectins (Angata and Brinkman-van der Linden, 2002; Kelm et al., 1994; Nath et al., 1995; Powell and Varki, 1994) and CSL, which is specific for oligomannosidic N-glycans with 6 mannose residues (Zanetta et al., 1987). The MR60-ERGIC-53 mannose-binding lectin (Arar et al., 1995; Fiedler and Simmons, 1994) is related to plant lectins. Besides these molecules involved either in homotypic or heterotypic cell adhesion, or in intracellular traffic of glycoconju-gates, those that are polyvalent (having two carbohydrate-recognition domains (CRD) or organized as oligomers) may have clustering effects on their ligands. This may represent the endogenous mechanism mimicked by specific polyvalent antibodies or plant lectins (Feizi and Childs, 1987). For example, the lectin CSL, which is rapidly over-expressed and externalized after stimulation of human cells with phorbol esters and binds to its surface ligands (including the glycosylated forms of CD3 on T cells and CD24 on B cells) is responsible for the major tyrosine-phosphorylation changes occurring in the early stages of cell activation (Zanetta et al., 1995).

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References

  • Akira, S., Hirano, T., Taga, T., and Kishimoto, T., 1990, Expression of interleukin-2 receptor gamma chain on human neutrophils, FASEB J. 4:2860–2867.

    PubMed  CAS  Google Scholar 

  • Angata, T. and Brinkman-van der Linden, 2002, E.C.M., I-type lectins, Biochim Biophys Acta. 1572:294–316.

    Article  PubMed  CAS  Google Scholar 

  • Arar, C., Carpentier, V., Le Caer, J.P., Monsigny, M., Legrand, A., and Roche, A.C., 1995, ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells, J Biol Chem. 270:3551–3553.

    Article  PubMed  CAS  Google Scholar 

  • Brody, D.T. and Durum, S.K., 1989, Membrane IL-1: IL-1 alpha precursor binds to the plasma membrane via a lectin-like interaction, J Immunol. 143:1183–1187.

    PubMed  CAS  Google Scholar 

  • Carter, D.B., Deibel Jr, M.R., Dunn, C.J., Tomich, C.S., Laborde, A.L., Slightom, J.L., Berger, A.E., Bienkowski, M.J., Sun, F.F., McEwan, R.N. et al., 1990, Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein, Nature. 344:633–638.

    Article  PubMed  CAS  Google Scholar 

  • Cebo, C., Dambrouck, T., Maes, E., Laden, C., Strecker, G., Michalski, J.C., and Zanetta, J.P., 2001, Recombinant human interleukins IL-1 alpha, IL-1 beta, IL-4, IL-6, and IL-7 show different and specific calcium-independent carbohydrate-binding properties, J Biol Chem. 276:5685–5691.

    Article  PubMed  CAS  Google Scholar 

  • Cebo, C., Durier, V., Lagant, P., Maes, E., Florea, D., Lefebvre, T., Strecker, G., Vergoten, G., and Zanetta, J.P., 2002, Function and molecular modelling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligands, J Biol Chem. 277:12246–12252.

    Article  PubMed  CAS  Google Scholar 

  • Christie, G., Dacey, I., and Weston, J., 1995, Identification of a soluble, high affinity human interleukin 4 binding protein in normal human urine, Cytokine. 7:305–310.

    Article  PubMed  CAS  Google Scholar 

  • Chu, J.W. and Sharom, F., 1995, Gangliosides interact with interleukin-4 and inhibit interleukin-4-stimulated helper T-cell proliferation, Immunology. 84:396–403.

    PubMed  CAS  Google Scholar 

  • Clarke, D., Katoh, O., Gibbs, R.V., Griffiths, S.D., and Gordon, M.Y., 1995, Interaction of interleukin 7 (IL-7) with glycosaminoglycans and its biological relevance, Cytokine. 7:325–330.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, F.E., Kosen, P.A., Kuntz, I.D., Epstein, L.B., Ciardelli, T.L., and Smith, K.A., 1986, Structure-activity studies of interleukin-2, Science. 234:349–352.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, D.N.W., 2002, Galectinomics: finding themes in complexity, Biochim Biophys Acta. 1572:209–231.

    Article  PubMed  CAS  Google Scholar 

  • Dinarello, C.A., 1994, The interleukin-1 family: 10 years of discovery, FASEB J. 8:1314–1325.

    PubMed  CAS  Google Scholar 

  • Ding, D.X., Vera, J.C., Heaney, M.L., and Golde, D.W., 1995, N-glycosylation of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit is essential for ligand binding and signal transduction, J Biol Chem. 270:24580–24584.

    Article  PubMed  CAS  Google Scholar 

  • Dodd, R.B. and Drickamer, K., 2001, Lectin-like proteins in model organisms: implications for evolution of carbohydrate-binding activity, Glycobiology. 11:71–79.

    Article  Google Scholar 

  • Drickamer, K., 1997, Making a fitting choice: common aspects of sugar-binding sites in plant and animal lectins, Structure. 5:465–468.

    Article  PubMed  CAS  Google Scholar 

  • Farrar, W.L., Garcia, G., Evans, G., Michiel, D., and Linnekin, D., 1990, Cytokine regulation of protein phosphorylation, Cytokine. 2:77–91.

    Article  PubMed  CAS  Google Scholar 

  • Feizi, T. and Childs, R.A., 1987, Carbohydrates as antigenic determinants of glycoproteins, Biochem J. 245:1–11.

    PubMed  CAS  Google Scholar 

  • Fernandez-Botran, R. and Vitetta, E.S., 1990, A soluble, high-affinity, interleukin-4-binding protein is present in the biological fluids of mice, Proc Natl Acad Sci USA. 87:4202–4206.

    Article  PubMed  CAS  Google Scholar 

  • Fiedler, K. and Simons, K., 1994, The role of N-glycans in the secretory pathway, Cell. 77:625–626.

    Article  PubMed  CAS  Google Scholar 

  • Fontaine, V., Ooms, J., and Content, J., 1994, Mutagenesis of the human interleukin-6 fourth predicted alpha-helix: involvement of the Arg 168 in the binding site, Eur J Immunol. 24:1041–1045.

    Article  PubMed  CAS  Google Scholar 

  • Fontaine, V., Savino, R., Arcone, R., de Wit, L., Brakenhoff, J.P., Content, J., and Ciliberto, G., 1993, Involvement of the Arg 179 in the active site of human IL-6, Eur J Biochem. 211:749–755.

    Article  PubMed  CAS  Google Scholar 

  • Foxall, C., Watson, S.R., Dowbenko, D., Fennie, C., Lasky, L.A., Kiso, M., Hasegawa, A., Asa, A., and Brandley, B.K., 1992, The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x) oligosaccharide, J Cell Biol. 117:895–902.

    Article  PubMed  CAS  Google Scholar 

  • Fukada, T., Yoshida, Y., Nishida, K., Ohtani, T., Shirogane, T., Hibi, M., and Hirano, T., 1999, Signalling through Gpl30: toward a general scenario of cytokine action, Growth Factors. 17:81–91.

    Article  PubMed  CAS  Google Scholar 

  • Fukushima, K. and Yamashita K., 2001, Carbohydrate recognition site of interleukin-2 in relation to cell proliferation, J Biol Chem. 276:7351–7356.

    Article  PubMed  CAS  Google Scholar 

  • Fukushima, K., Hara-Kuge, S., Ohkura, T., Seko, A., Ideo, H., Inazu, T., and Yamashita, K., 1997, Lectin-like characteristics of recombinant human interleukin-lbeta recognizing glycans of the glycosylphos-phatidylinositol anchor, J Biol Chem. 272:10579–10584.

    Article  PubMed  CAS  Google Scholar 

  • Fukushima, K., Watanabe, H., Takeo, K., Nomura, M., Asahi, T., and Yamashita, K., 1993, N-linked sugar chain structure of recombinant human lymphotoxin produced by CHO cells: the functional role of carbohydrate as to its lectin-like character and clearance velocity, Arch Biochem Biophys. 304:144–153.

    Article  PubMed  CAS  Google Scholar 

  • Hatakeyama, M., Kono, T., Kobayashi, N., Kawahara, A., Levin, S.D., Perlmutter, R.M., and Taniguchi, T., 1991, Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA’s, Science. 252:1523–1528.

    Article  PubMed  CAS  Google Scholar 

  • Hession, C., Decker, J.M., Sherblom, A.P., Kumar, S., Yue, C.C., Mattallano, R.J., Tizard, R., Kawashima, E., Schmeissner, U., Heletky, S., Chow, E.P., Burne, C.A., Shaw, A., and Muchmore, A.V., 1987, Uromodulin (Tamm-Horsfall glycoprotein): a renal ligand for lymphokines, Science. 237:1479–1484.

    Article  PubMed  CAS  Google Scholar 

  • Hirano, T., 1998, Interleukin 6 and its receptor: ten years later, Int Rev Immunol. 16:249–284.

    Article  PubMed  CAS  Google Scholar 

  • Hirano, T., Nakajima, K., and Hibi, M., 1997, Signalling mechanisms through gp130: a model of the cytokine system, Cytokine Growth Factor Rev. 8:241–252.

    Article  PubMed  CAS  Google Scholar 

  • Horak, I., 1995, Immunodeficiency in IL-2-knockout mice, Clin Immunol Immunopathol. 76:172–173.

    Article  Google Scholar 

  • Huang, H. and Paul, W.E., 2000, Protein tyrosine phosphatase activity is required for IL-4 induction of IL-4 receptor alpha-chain, J Immunol. 164:1211–1215.

    PubMed  CAS  Google Scholar 

  • Imani, F, Rager, K.J., Catipovic, B., and Marsh, D.G., 1997, Interleukin-4 (IL-4) induces phosphatidylinositol 3-kinase (p85) dephosphorylation. Implications for the role of SHP-1 in the IL-4-induced signals in human B cells, J Biol Chem. 272:7927–7931.

    Article  PubMed  CAS  Google Scholar 

  • Ju, G., Collins, L., Kaffka, K.L., Tsien, W.H., Chizzonite, R., Crowl, R., Bhatt, R., and Kilian, P.L., 1987, Structure-function analysis of human interleukin-2. Identification of amino acid residues required for biological activity, J Biol Chem. 262:5723–5731.

    PubMed  CAS  Google Scholar 

  • Kamegai, M., Niijima, K., Kunishita, T., Nishizawa, M., Ogawa, M., Araki, M., Ueki, A., Konishi, Y., and Tabira, T., 1990, Interleukin 3 as a trophic factor for central cholinergic neurons in vitro and in vivo, Neuron. 4:429–436.

    Article  PubMed  CAS  Google Scholar 

  • Kaplan, D., Smith, D., Huang, R., and Yildirim, Z., 1995, Self-association of interleukin 2 bound to its receptor, FASEB J. 9:1096–1102.

    PubMed  CAS  Google Scholar 

  • Kawasaki T., 1999, Structure and biology of mannan-binding protein, MBP, an important component of innate immunity, Biochim Biophys Acta. 1473:186–195.

    Article  PubMed  CAS  Google Scholar 

  • Kelm, S., Schauer, R., Manuguerra, J.C., Gross H.J., and Crocker, P.R., 1994, Modifications of cell surface sialic acids modulate cell adhesion mediated by sialoadhesin and CD22, Glycoconjugate J 11:576–585.

    Article  CAS  Google Scholar 

  • Kilpatrick, D., 2002, Animal lectins: a historical introduction and overview, Biochim Biophys Acta. 1572:187–197.

    Article  PubMed  CAS  Google Scholar 

  • Kilpatrick, D.C., 2002, Mannan-binding lectin: clinical significance and applications, Biochim Biophys Acta. 1572, 401–413.

    Article  PubMed  CAS  Google Scholar 

  • Kishimoto, T., Taga, T., and Akira S., 1992a, Cytokine signal transduction, Cell. 76:253–262.

    Article  Google Scholar 

  • Kishimoto, T., Akira, S., and Taga, T., 1992b, Interleukin-6 and its receptor: a paradigm for cytokines, Science. 258:593–597.

    Article  PubMed  CAS  Google Scholar 

  • Kolb, J.P. and Abadie, A., 1993, Inhibitors of protein tyrosine kinases and protein tyrosine phosphatases suppress IL-4-induced CD23 expression and release by human B lymphocytes, Eur Cytokine Netw. 4:429–438.

    PubMed  CAS  Google Scholar 

  • Konishi, Y., Chui, D.H., Kunishita, T., Yamamura, T., Higashi, Y., and Tabira, T., 1995, Demonstration of interleukin-3 receptor-associated antigen in the central nervous system, J Neurosci Res. 41:572–582.

    Article  PubMed  CAS  Google Scholar 

  • Lasky, L.A., 1992, Selectins: interpreters of cell-specific carbohydrate information during inflammation, Science. 258:964–969.

    Article  PubMed  CAS  Google Scholar 

  • Leebeck, F.W., Kariya, K., Schwabe, M., and Fowlkes, D.M., 1992, Identification of a receptor binding site in the carboxyl terminus of human interleukin-6, J Biol Chem. 267:14832–14838.

    Google Scholar 

  • Lescar, J., Loris, R., Mitchell, E., Gautier, C., Chazalet, V., Cox, V., Wyns, L., Perez, S., Breton, C., and Imberty, A., 2002, Isolectins I-A and I-B of Griffonia (Bandeiraea) simplicifolia. Crystal structure of metal-free GS I-B(4) and molecular basis for metal binding and monosaccharide specificity, J Biol Chem. 277:6608–6614.

    Article  PubMed  CAS  Google Scholar 

  • Li, X., Rock, F., Chong, P., Cockle, S., Keating, A., Ziltener, H., and Klein, M., 1993, Structure-function analysis of the C-terminal segment of human interleukin-6, J Biol Chem. 268:22377–22384.

    PubMed  CAS  Google Scholar 

  • Licinio, J. and Wong, M.L., 1996, Interleukin 1 beta and fever, Nat Med. 2:1314–1315.

    Article  PubMed  CAS  Google Scholar 

  • Lobsanov, Y.D., Gitt, M.A., Leffler, H., Barondes, S.H., and Rini, J.M., 1993, X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution, J Biol Chem. 268:27034–27038.

    PubMed  CAS  Google Scholar 

  • Lokker, N.A., Movva, N.R., Strittmatter, U., Fagg, B., and Zenke, G., 1991, Structure-activity relationship study of human interleukin-3. Identification of residues required for biological activity by site-directed mutagenesis, J Biol Chem. 266:10624–10631.

    PubMed  CAS  Google Scholar 

  • Luton, F., Legendre, V., Gorvel, J.P., Schmitt-Verhulst, A.M., and Boyer, C., 1997, Tyrosine and serine protein kinase activities associated with ligand-induced internalized TCR/CD3 complexes, J Immunol. 158:3140–3147.

    PubMed  CAS  Google Scholar 

  • Mancilla, J., Ikejima, T., and Dinarello, C.A., 1992, Glycosylation of the interleukin-1 receptor type I is required for optimal binding of interleukin-1, Lymphokine Cytokine Res. 11:197–205.

    PubMed  CAS  Google Scholar 

  • Mori, K., Kawasaki, T., Yamashina, I., 1988, Isolation and characterization of endogenous ligands for liver mannan-binding protein, Arch Biochem Biophys. 264:647–656.

    Article  PubMed  CAS  Google Scholar 

  • Muchmore, A.V and Decker, J.M., 1986, Uromodulin. An immunosuppressive 85-kilodalton glycoprotein isolated from human pregnancy urine is a high affinity ligand for recombinant interleukin 1 alpha, J Biol Chem. 261:13404–13407.

    PubMed  CAS  Google Scholar 

  • Muchmore, A.V and Decker, J.M., 1987, The lectin-like interaction between recombinant tumor necrosis factor and uromodulin, J Immunol. 138:2541–2546.

    PubMed  CAS  Google Scholar 

  • Nath, D., van der Merwe, P.A., Kelm, S., Bradfield, P., and Crocker, P.R., 1995, The amino-terminal immunoglobulin-like domain of sialoadhesin contains the sialic acid binding site. Comparison with CD22, J Biol Chem. 270:26184–26191.

    Article  PubMed  CAS  Google Scholar 

  • Nelms, K., Keegan, A.D., Zamorano, J., Ryan, J.J., and Paul, W.E., 1999, The IL-4 receptor: signalling mechanisms and biologic functions, Annu Rev Immunol. 17:701–738.

    Article  PubMed  CAS  Google Scholar 

  • Niu, L., Heaney, M.L., Vera, J.C., and Golde, D.W., 2000, High-affinity binding to the GM-CSF receptor requires intact N-glycosylation sites in the extracellular domain of the beta subunit, Blood. 95:3357–3362.

    PubMed  CAS  Google Scholar 

  • Noguchi, N., Nakamura, Y., Russell, S.M., Ziegler, S.F., Tsang, M., Cao, X., and Leonard, W.J., 1993, Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor, Science. 262:1877–1880.

    Article  PubMed  CAS  Google Scholar 

  • Normand, G., Kuchler, S., Meyer, A., Vincendon, G., and Zanetta, J.P., 1988, Isolation and immunohistochemical localization of a chondroitin sulfate proteoglycan from adult rat brain, J Neurochem. 51:665–676.

    Article  PubMed  CAS  Google Scholar 

  • Ozawa, H., Kotani, M., Kawashima, I., Numata, M., Ogawa, T., Terashima, T., and Tai, T., 1993, Generation of a monoclonal antibody specific for ganglioside GM4: evidence for GM4 expression on astrocytes in chicken cerebellum, J Biochem. 114:5–8.

    PubMed  CAS  Google Scholar 

  • Paonessa, G., Graziani, R., de Serio, A., Savino, R., Ciapponi, L., Lahm, A., Salvati, A.L., Toniatti, C., and Ciliberto, G., 1995, Definition of a composite binding site for gp130 in human interleukin-6, EMBO J. 14:1942–1951.

    PubMed  CAS  Google Scholar 

  • Paul, W.E., 1991, Interleukin-4: a prototypic immunoregulatory lymphokine, Blood. 77:1859–1870.

    PubMed  CAS  Google Scholar 

  • Powell, L.D. and Varki, A., 1994, CD22-mediated cell adhesion to cytokine-activated human endothelial cells. Positive and negative regulation by alpha 2–6-sialylation of cellular glycoproteins, J Biol Chem. 269:10628–10636.

    PubMed  CAS  Google Scholar 

  • Sauter, N.K., Glick, G.D., Crowther, R.L., Park, S.J., Eisen, M.B., Skehel, J.J., Knowles, J.R., and Wiley, D.C., 1992, Crystallographic detection of a second ligand binding site in influenza virus hemagglutinin, ProcNatl Acad Sci USA. 89:324–328.

    Article  CAS  Google Scholar 

  • Savino, R., Ciapponi, L., Lahm, A., Demartis, A., Cabibbo, A., Toniatti, C., Delmastro, P., Altamura, S., and Ciliberto, G., 1994, Rational design of a receptor super-antagonist of human interleukin-6, EMBO J. 13:5863–5870.

    PubMed  CAS  Google Scholar 

  • Savino, R., Lahm, A., Giorgio, A., Cabiddo, A., Tramontano, A., and Ciliberto, G., 1993, Saturation mutagenesis of the human interleukin 6 receptor-binding site: implications for its three-dimensional structure, ProcNatl Acad Sci USA. 9:4067–4071.

    Article  Google Scholar 

  • Schaaf-Lafontaine, N., Balthazart, C., and Hooghe, R.J., 1985, Membrane carbohydrates of lymphoid cells: the receptor for interleukin 2, Immunobiology. 170:249–255.

    Article  PubMed  CAS  Google Scholar 

  • Sherblom, A.P., Decker, J.M., and Muchmore, A.V., 1988, The lectin-like interaction between recombinant tumor necrosis factor and uromodulin, J Biol Chem. 263:5418–5424.

    PubMed  CAS  Google Scholar 

  • Sherblom, A.P., Sathyamoorthy, N., Decker, J.M., and Muchmore, A.V., 1989, IL-2, a lectin with specificity for high mannose glycopeptides, J Immunol. 143:939–944.

    PubMed  CAS  Google Scholar 

  • Shibuya, H., Kohu, K., Yamada, K., Barsoumian, E.L., Perlmutter, R.M., and Taniguchi, T., 1994, Functional dissection of p561ck, a protein tyrosine kinase which mediates interleukin-2-induced activation of the c-fos gene, Mol Cell Biol. 14:5812–5819.

    Article  PubMed  CAS  Google Scholar 

  • Shibuya, K., Chiba, S., Miyagawa, K., Kitamura, T., Miyazono, K., and Takaku, F., 1991, Structural and functional analyses of glycosylation on the distinct molecules of human GM-CSF receptors, Eur J Biochem. 198:659–666.

    Article  PubMed  CAS  Google Scholar 

  • Siebert, H.C., Adar, R., Arango, R., Burchert, M., Kaltner, H., Kayser, G., Tajkhorshid, E., von der Lieth, C.W., Kaptein, R., Sharon, N., Vliegenthart, J.F.G., and Gabius, H.J., 1997, Involvement of laser photo-CIDNP (chemically induced dynamic nuclear polarization)-reactive amino acid side chains in ligand binding by galactoside-specific lectins in solution, Eur J Biochem. 249:27–38.

    Article  PubMed  CAS  Google Scholar 

  • Somers, W., Stahl, M., and Seehra, J.S., 1997, 1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signalling, EMBO J. 16:989–997.

    Article  PubMed  CAS  Google Scholar 

  • Stein, P.E., Boodhoo, A., Armstrong, G.D., Heerze, L.D., Cockle, S.A., Klein, M.H., and Read, R.J., 1994, Structure of a pertussis toxin-sugar complex as a model for receptor binding, Nat Struct Biol. 1:591–596.

    Article  PubMed  CAS  Google Scholar 

  • Takeshita, T., Asao, H., Ohtani, K., Ishii, N., Kumaki, S., Tanaka, N., Munakata, H., Nakamura, M., and Sugamura, K., 1992, Cloning of the gamma chain of the human IL-2 receptor, Science. 257:379–382.

    Article  PubMed  CAS  Google Scholar 

  • Taniguchi, T. and Minami, Y., 1993, The IL-2/IL-2 receptor system: a current overview, Cell. 73:5–8.

    Article  PubMed  CAS  Google Scholar 

  • Waldmann, T.A., 1991, The interleukin-2 receptor, J Biol Chem. 266:2681–2684.

    PubMed  CAS  Google Scholar 

  • Wall, K.A., Pierce, J.D., and Elbein, A.D. Inhibitors of glycoprotein processing alter T-cell proliferative responses to antigen and to interleukin 2, Proc Natl Acad Sci USA. 85:5644–5648.

    Google Scholar 

  • Wells, T.N.C., Graber, P., Proudfoot, A.E.I., Arod, C.Y., Jordan, S.R., Lambert, M.H., Hassel, A.M., and Milburn, M.V., 1994, The three-dimensional structure of human interleukin-5 at 2.4-angstroms resolution: implication for the structures of other cytokines, Ann N Y Acad Sci. 725:118–127.

    Article  PubMed  CAS  Google Scholar 

  • Winkelstein, A., Muchmore, A.V., Decker, J.M., and Blaese, R.M., 1990, Uromodulin: a specific inhibitor of IL-1-initiated human T cell colony formation, Immunopharmacol. 20:201–205.

    Article  CAS  Google Scholar 

  • Yasueda, H., Miyasaka, Y., Shimamura, T., and Matsui, H., 1992, Effect of semi-random mutagenesis at the C-terminal 4 amino acids of human interleukin-6 on its biological activity, Biochem Biophys Res Commun. 187:18–25.

    Article  PubMed  CAS  Google Scholar 

  • Zanetta, J.P., Alonso, C., and Michalski, J.C., 1996, Interleukin 2 is a lectin that associates its receptor with the T-cell receptor complex, Biochem J. 318:49–53.

    PubMed  CAS  Google Scholar 

  • Zanetta, J.P., Bindeus, R., Normand, G., Durier, V., Lagant, P., Maes, E., and Vergoten, G., 2002, Evidence for a lectin activity for human interleukin-3 and modelling of its carbohydrate-recognition domain, J Biol Chem. 277:38764–38771.

    Article  PubMed  CAS  Google Scholar 

  • Zanetta, J.P., Bonaly, R., Maschke, S., Strecker, G., and Michalski, J.C., 1988, Differential binding of lectins IL-2 and CSL to Candida albicans and cancer cells, Glycobiology. 8:221–225.

    Article  Google Scholar 

  • Zanetta, J.P., Bonaly, R., Maschke, S., Strecker, G., and Michalski, J.C., 1988, Hypothesis: Immunodeficiencies in α-mannosidosis, mycosis, aids and cancer: a common mechanism of inhibition of the function of interleukin 2 by oligomannosides, Glycobiology. 8:v–xi.

    Google Scholar 

  • Zanetta, J.P., Meyer, A., Kuchler, S., and Vincendon, G., 1987, Isolation and immunochemical study of a soluble cerebellar lectin delineating its structure and function, J Neurochem. 49:1250–1257.

    Article  PubMed  CAS  Google Scholar 

  • Zanetta, J.P., Pons, A., Iwersen, M., Mariller, C., Leroy, Y., Timmerman, P., and Schauer, R., 2001, Diversity of sialic acids revealed using gas chromatography/mass spectrometry of heptafluorobutyrate derivatives, Glycobiology. 11:663–676.

    Article  PubMed  CAS  Google Scholar 

  • Zanetta, J.P., Wantyghem, J., Kuchler-Bopp, S., Badache, A., and Aubery, M., 1995, Human lymphocyte activation is associated with the early and high-level expression of the endogenous lectin CSL at the cell surface, Biochem J. 311:629–636.

    PubMed  CAS  Google Scholar 

  • Zola, H., Weedon, H., Thompson, G.R., Fung, M.C., Ingley, E., and Hapel, A.J., 1991, Expression of IL-2 receptor p55 and p75 chains by human B lymphocytes: effects of activation and differentiation, Immunology. 72:167–173.

    PubMed  CAS  Google Scholar 

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  1. CNRS Unité Mixte de Recherche 8576 Laboratoire de Glycobiologie Structurale et Fonctionnelle Université des Sciences et Technologies de Lille, Bâtiment C9, 59655, Villeneuve d’Ascq Cedex, France

    Jean-Pierre Zanetta & Gérard Vergoten

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Zanetta, JP., Vergoten, G. (2003). Lectin Domains on Cytokines. In: Axford, J.S. (eds) Glycobiology and Medicine. Advances in Experimental Medicine and Biology, vol 535. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0065-0_8

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  • DOI: https://doi.org/10.1007/978-1-4615-0065-0_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4908-2

  • Online ISBN: 978-1-4615-0065-0

  • eBook Packages: Springer Book Archive

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