Structural Basis for Bacterial Adhesion in the Urinary Tract

  • Jenny Berglund
  • Stefan D. Knight
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 535)


Most bacterial infections occur in the respiratory, gastrointestinal, or urinary tract. These spaces offer attractive advantages for bacteria in the form of nutrient availability, and are readily accessible from the outside world. In many cases bacterial habitation is not compatible with well being of the host, and mammals have developed powerful counter-measures and clearance mechanisms in order to limit bacterial colonization. Pathogenic bacteria have in turn developed solutions to overcome these challenges. One of the first obstacles facing bacteria striving to colonize one of the epithelial tracts is the cleansing action exerted by the flow of, for example, saliva, mucus, or urine. It is therefore no surprise that bacterial pathogenesis frequently involves adhesion of the pathogen to host epithelial tissues, and that adhesion in many cases is a first crucial event in establishing colonization and infection.


Bacterial Adhesion Yersinia Pestis Lectin Domain Pilus Assembly Sugar Binding Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Jenny Berglund
    • 1
  • Stefan D. Knight
    • 1
  1. 1.Department of Molecular Biosciences/Structural BiologyUppsala Biomedical Center Swedish University of Agricultural SciencesUppsalaSweden

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